Cancer metabolic reprogramming has been considered an emerging hallmark in
tumorigenesis and the antitumor immune response. Like cancer cells, immune cells within …

This review article aims to significantly advance the scientific community's efforts to develop
effective nucleoside‐based drugs for treating severe acute respiratory syndrome …

Many individuals with cancer are resistant to immunotherapies. Here, we identify the gene
encoding the pyrimidine salvage pathway enzyme cytidine deaminase (CDA) among the top …

Glucose is vital for life, serving as both a source of energy and carbon building block for
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …

The complexity of the tumor microenvironment (TME) is a crucial factor in lung
adenocarcinoma (LUAD) progression. To gain deeper insights into molecular mechanisms …

Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of
about 25% and no approved therapy. Using metabolomic and proteomic analyses, we …

UPP1, a crucial pyrimidine metabolism-related enzyme, catalyzes the reversible
phosphorylation of uridine to uracil and ribose-1-phosphate. However, the effects of UPP1 in …

From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and
circulate throughout the body and tissues. Nucleosides and nucleotides are classically …

Pancreatic cancer is a highly malignant solid tumor with a poor prognosis and a high
mortality rate. Thus, exploring the mechanisms underlying the development and progression …

Uridine is a pyrimidine nucleoside found in plasma and cerebrospinal fluid with a
concentration higher than the other nucleosides. As a simple metabolite, uridine plays a …