SARS-CoV-2 evolution from the BA. 2.86 to JN. 1 variants: unexpected consequences

X Wang, L Lu, S Jiang - Trends in immunology, 2024 - cell.com
SARS-CoV-2 is continuously evolving. The Omicron subvariant BA. 2.86, with> 30 mutations
in its spike (S) protein compared with its predecessor strain BA. 2, was expected to quickly …

Sotrovimab: a review of its efficacy against SARS-CoV-2 variants

D Focosi, A Casadevall, M Franchini, F Maggi - Viruses, 2024 - mdpi.com
Among the anti-Spike monoclonal antibodies (mAbs), the S-309 derivative sotrovimab was
the most successful in having the longest temporal window of clinical use, showing a high …

[HTML][HTML] Early estimates of updated 2023–2024 (monovalent XBB. 1.5) COVID-19 vaccine effectiveness against symptomatic SARS-CoV-2 infection attributable to co …

R Link-Gelles - MMWR. Morbidity and mortality weekly report, 2024 - cdc.gov
Abstract On September 12, 2023, CDC's Advisory Committee on Immunization Practices
recommended updated 2023–2024 (updated) COVID-19 vaccination with a monovalent …

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN. 1

F Jian, J Wang, A Yisimayi, W Song, Y Xu, X Chen… - Nature, 2024 - nature.com
The continuous evolution of SARS-CoV-2, particularly the emergence of BA. 2.86/JN. 1
lineage replacing XBB, necessitates re-evaluation of vaccine compositions 1–3. Here, we …

Virological characteristics of the SARS-CoV-2 KP. 2 variant

Y Kaku, K Uriu, Y Kosugi, K Okumura… - The Lancet Infectious …, 2024 - thelancet.com
The JN. 1 variant (BA. 2.86. 1.1), arising from BA. 2.86. 1 with the S: L455S substitution,
showed increased fitness and outcompeted the previous dominant XBB lineage by the …

[HTML][HTML] Virological characteristics of the SARS-CoV-2 KP. 3, LB. 1, and KP. 2.3 variants

Y Kaku, MS Yo, JE Tolentino, K Uriu… - The Lancet infectious …, 2024 - thelancet.com
Virological characteristics of the SARS-CoV-2 KP.3, LB.1, and KP.2.3 variants - The Lancet
Infectious Diseases Skip to Main Content Skip to Main Menu Advertisement The Lancet …

Neutralization escape, infectivity, and membrane fusion of JN. 1-derived SARS-CoV-2 SLip, FLiRT, and KP. 2 variants

P Li, JN Faraone, CC Hsu, M Chamblee, YM Zheng… - Cell reports, 2024 - cell.com
We investigate JN. 1-derived subvariants SLip, FLiRT, and KP. 2 for neutralization by
antibodies in vaccinated individuals, severe acute respiratory syndrome coronavirus 2 …

Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA. 2.86/JN. 1 and EG. 5.1/HK. 3

Y Liu, X Zhao, J Shi, Y Wang, H Liu, YF Hu… - Nature …, 2024 - nature.com
Abstract SARS-CoV-2 JN. 1 with an additional L455S mutation on spike when compared
with its parental variant BA. 2.86 has outcompeted all earlier variants to become the …

Relative vaccine protection, disease severity, and symptoms associated with the SARS-CoV-2 omicron subvariant BA. 2.86 and descendant JN. 1 in Denmark: a …

IR Moustsen-Helms, P Bager, TG Larsen… - The Lancet Infectious …, 2024 - thelancet.com
Summary Background During the 2023 Danish COVID-19 vaccination campaign, an
updated monovalent mRNA vaccine targeting the SARS-CoV-2 omicron XBB. 1.5 subvariant …

Structural basis for the evolution and antibody evasion of SARS-CoV-2 BA. 2.86 and JN. 1 subvariants

H Yang, H Guo, A Wang, L Cao, Q Fan, J Jiang… - Nature …, 2024 - nature.com
The Omicron subvariants of SARS-CoV-2, especially for BA. 2.86 and JN. 1, have rapidly
spread across multiple countries, posing a significant threat in the ongoing COVID-19 …