Synaptic connections are essential for neural circuits in order to convey brain functions. The
postsynaptic density (PSD) is a huge protein complex associated with postsynaptic …

Psychiatric disorders represent a great medical and social challenge and people suffering
from these conditions face many impairments regarding personal and professional life. In …

Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

Synaptic dysfunction is implicated in the pathophysiology of schizophrenia (SCZ) and
bipolar disorder (BP). We use quantitative mass spectrometry to carry out deep, unbiased …

The L-type calcium channels (LTCCs) Ca v 1.2 and Ca v 1.3, encoded by the CACNA1C
and CACNA1D genes, respectively, are important regulators of calcium influx into cells and …

Postsynaptic proteins play crucial roles in synaptic function and plasticity. During brain
development, alterations in synaptic number, shape, and stability occur, known as synapse …

Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau
neuropathology. While this neuropathology is necessary for AD diagnosis, it is not sufficient …

Genes encoding synaptic proteins are highly associated with neuronal disorders many of
which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets …

Objective: The shared risk factors and clinical features in schizophrenia and bipolar disorder
may be linked via mitochondrial dysfunction. However, the severity of mitochondrial …

Genome-wide association studies (GWAS) have revealed multiple genomic loci conferring
risk of bipolar disorder (BD), providing hints for its underlying pathobiology. However, there …