In this era of jet travel, our body'remembers' the previous time zone, such that when we
travel, our sleep–wake pattern, mental alertness, eating habits and many other physiological …

Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the
most common type of dementia. Along with progressive cognitive impairment, dysfunction of …

Light is a major environmental signal for circadian rhythms. We have identified and analyzed
cry, a novel Drosophila cryptochrome gene. All characterized family members are directly …

The circadian clock is a widespread cellular mechanism that underlies diverse rhythmic
functions in organisms from bacteria and fungi, to plants and animals. Intense genetic …

We have isolated three alleles of a novel Drosophila clock gene, double-time (dbt). Short-
(dbt S) and long-period (dbt L) mutants alter both behavioral rhythmicity and molecular …

Eclosion, or emergence of adult flies from the pupa, and locomotor activity of adults occur
rhythmically in Drosophila melanogaster, with a circadian period of about 24 hours. Here, a …

Many biochemical, physiological and behavioural processes in organisms ranging from
microorganisms to vertebrates exhibit circadian rhythms. In Drosophila, the gene period …

The cloning of double-time (dbt) is reported. DOUBLETIME protein (DBT) is most closely
related to human casein kinase Iε. dbt S and dbt L mutations, which alter period length of …

Genes are understandably crucial to physiology, morphology and biochemistry, but the idea
of genes contributing to individual differences in behaviour once seemed outrageous …

Tissue-specific overexpression of the glycogen synthase kinase-3 (GSK-3) ortholog shaggy
(sgg) shortens the period of the Drosophila circadian locomotor activity cycle. The short …