Epithelial–mesenchymal transitions (EMTs) are the epitome of cell plasticity in embryonic
development and cancer; during EMT, epithelial cells undergo dramatic phenotypic changes …

Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

The lung is an architecturally complex organ comprising a heterogeneous mixture of various
epithelial and mesenchymal lineages. We use single-cell RNA sequencing and signaling …

Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

The diversity of mesenchymal cell types in the lung that influence epithelial homeostasis and
regeneration is poorly defined. We used genetic lineage tracing, single-cell RNA …

Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

The respiratory tract is a vital, intricate system for several important biological processes
including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling …