Autosomal dominant polycystic kidney disease (ADPKD) is a progressive inherited disorder
in which renal tissue is gradually replaced with fluid-filled cysts, giving rise to chronic kidney …

Normal cellular function is maintained by coordinated proteome machinery that performs a
vast array of activities. Hel** the proteome in such roles is the chaperome, a network of …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by renal cyst
formation, inflammation, and fibrosis. Macrophages infiltrate cystic kidneys, but the role of …

Autosomal dominant polycystic kidney disease (ADPKD) is driven by mutations in PKD1 and
PKD2 genes. Recent work suggests that epigenetic modulation of gene expression and …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in either
PKD1 or PKD2. It is one of the most common heritable human diseases with eventual …

Clinical treatment of candidiasis has suffered from increasingly severe drug resistance and
limited efficacy. Thus, novel strategies to deal with drug resistance are highly desired to …

Introduction Renal ciliopathies represent a collection of genetic disorders characterized by
deficiencies in the biogenesis, maintenance, or functioning of the ciliary complex. These …

In this study, we identified a BET bromodomain (BRD) protein, Brd4, not only as a novel
epigenetic regulator of autosomal dominant polycystic kidney disease (ADPKD) but also as …

Signal transducers and activators of transcription (STATs) are latent, cytoplasmic
transcription factors. Janus kinases (JAKs) and activated CDC42-associated kinase-1 …

The transcription factors Myc and p53 associated with oncogenesis play determinant roles in
a human genetic disorder, autosomal dominant polycystic kidney disease (ADPKD), that …