Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
Y Liu, L Li, P Ren - US Patent 10,646,488, 2020 - Google Patents
(57) ABSTRACT 3,702,849 A 3,752,660 A 4,439,606 A 4,649,219 A 4,656,181 A 4,861,760
A 4,911,920 A 5,010,175 A 5,033,252 A 5,052,558 A 5,212,162 A 5,288,514 A 5,323,907 A …
A 4,911,920 A 5,010,175 A 5,033,252 A 5,052,558 A 5,212,162 A 5,288,514 A 5,323,907 A …
Substituted quinazolines as inhibitors of KRAS G12C
L Li, J Feng, T Wu, P Ren, Y Liu, Y Liu… - US Patent …, 2017 - Google Patents
2015-05-18 Assigned to ARAXES PHARMA LLC reassignment ARAXES PHARMA LLC
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
Combination therapies for treatment of cancer
MR Janes, MP Patricelli, L Li, P Ren, Y Liu - US Patent 10,111,874, 2018 - Google Patents
2016-03-02 Assigned to ARAXES PHARMA LLC reassignment ARAXES PHARMA LLC
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
Substituted quinazoline compounds and methods of use thereof
L Li, J Feng, YO Long, Y Liu, T Wu, P Ren… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
55754477&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
55754477&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
L Li, J Feng, YO Long, Y Liu, T Wu, P Ren… - US Patent …, 2019 - Google Patents
2017-03-28 Assigned to ARAXES PHARMA LLC reassignment ARAXES PHARMA LLC
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
Covalent inhibitors of K-Ras G12C
P Ren, Y Liu, L Li, J Feng, T Wu - US Patent 9,926,267, 2018 - Google Patents
XKMLYUALXHKNFT-UUOKFMHZSA-N Guanosine-5'-triphosphate Chemical compound
C1= 2NC (N)= NC (= O) C= 2N= CN1 [C@@ H] 1O [C@ H](COP (O)(= O) OP (O)(= O) OP …
C1= 2NC (N)= NC (= O) C= 2N= CN1 [C@@ H] 1O [C@ H](COP (O)(= O) OP (O)(= O) OP …
Inhibitors of KRAS G12C mutant proteins
L Li, J Feng, YO Long, Y Liu, P Ren, Y Liu - US Patent 10,975,071, 2021 - Google Patents
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The
compounds have the fol lowing structure (I): or a pharmaceutically acceptable salt, tautomer …
compounds have the fol lowing structure (I): or a pharmaceutically acceptable salt, tautomer …
Inhibitors of KRAS G12C mutant proteins
L Li, J Feng, YO Long, Y Liu, P Ren, Y Liu - US Patent 10,280,172, 2019 - Google Patents
US10280172B2 - Inhibitors of KRAS G12C mutant proteins - Google Patents US10280172B2 -
Inhibitors of KRAS G12C mutant proteins - Google Patents Inhibitors of KRAS G12C mutant …
Inhibitors of KRAS G12C mutant proteins - Google Patents Inhibitors of KRAS G12C mutant …
Substituted quinazoline compounds and methods of use thereof
L Li, J Feng, YO Long, Y Liu, T Wu, P Ren… - US Patent …, 2018 - Google Patents
11/1972 Cronin et al. 8/1973 Little 3/1984 Du et al. 3/1987 Itoh et al. 8/1989 Mazuel et al.
3/1990 Jani et al. 4/1991 Rutter et al. 7/1991 Carter 10/1991 Carter or a pharmaceutically …
3/1990 Jani et al. 4/1991 Rutter et al. 7/1991 Carter 10/1991 Carter or a pharmaceutically …
Irreversible covalent inhibitors of the GTPase K-Ras G12C
P Ren, Y Liu, L Li, J Feng - US Patent 9,745,319, 2017 - Google Patents
Irreversible inhibitors of K-Ras, H-Ras or N-ras protein comprising a G12C mutation are
provided. Also disclosed are methods to regulate the activity of K-Ras, H-Ras or N-ras …
provided. Also disclosed are methods to regulate the activity of K-Ras, H-Ras or N-ras …