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Targeting Metalloenzymes: The “Achilles' Heel” of Viruses and Parasites
Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic
functions, including protein degradation, nucleic acid modification, and many others. Given …
functions, including protein degradation, nucleic acid modification, and many others. Given …
Recent report on indoles as a privileged anti-viral scaffold in drug discovery
A Singh, C Bhutani, P Khanna, S Talwar… - European Journal of …, 2024 - Elsevier
In recent years, viral infections such as COVID-19, Zika virus, Nipah virus, Ebola, Influenza,
Monkeypox, and Dengue have substantially impacted global health. These outbreaks have …
Monkeypox, and Dengue have substantially impacted global health. These outbreaks have …
[HTML][HTML] Inhibitory interactions of the 2, 3-dihydro-6, 7-dihydroxy-1H-isoindol-1-one scaffold with Bunyavirales cap-snatching endonucleases expose relevant drug …
F Miglioli, S Joel, M Tegoni, P Neira-Pelén… - European Journal of …, 2024 - Elsevier
Abstract The World Health Organization (WHO) identifies several bunyaviruses as significant
threats to global public health security. Develo** effective therapies against these viruses …
threats to global public health security. Develo** effective therapies against these viruses …
Antiviral compounds to address influenza pandemics: an update from 2016-2022
R Romeo, L Legnani, MA Chiacchio… - Current Medicinal …, 2024 - benthamdirect.com
In recent decades, the world has gained experience of the dangerous effects of pandemic
events caused by emerging respiratory viruses. In particular, annual epidemics of influenza …
events caused by emerging respiratory viruses. In particular, annual epidemics of influenza …
Design and synthesis of 7-membered lactam fused hydroxypyridinones as potent metal binding pharmacophores (MBPs) for inhibiting influenza virus PAN …
L Zhang, D Ke, Y Li, H Zhang, X Zhang, S Wang… - European Journal of …, 2024 - Elsevier
Since influenza virus RNA polymerase subunit PA N is a dinuclear Mn 2+ dependent
endonuclease, metal-binding pharmacophores (MBPs) with Mn 2+ coordination has been …
endonuclease, metal-binding pharmacophores (MBPs) with Mn 2+ coordination has been …
3'‐Dehydroxypurpurogallin‐4‐Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure‐Activity Relationship Analysis, and Structural …
M Kráľ, T Kotačka, R Reiberger, G Panýrková… - …, 2024 - Wiley Online Library
The influenza RNA‐dependent RNA polymerase harbours an endonuclease subunit
characterized by a catalytic site housing two divalent metal ions. By effectively chelating both …
characterized by a catalytic site housing two divalent metal ions. By effectively chelating both …
Optimization and biological evaluation of l-DOPA derivatives as potent influenza PAN endonuclease inhibitors with multi-site binding characteristics
J Ruan, K Lu, J He, Y Chen, B Li, X Wan, X Chen… - Bioorganic …, 2024 - Elsevier
Emerging and potential influenza pandemics still are an enormous worldwide public health
challenge. The PA N endonuclease has been proved to be a promising target for anti …
challenge. The PA N endonuclease has been proved to be a promising target for anti …
Optimization And Biological Evaluation of L-DOPA Derivatives as Potent Influenza PA N Endonuclease Inhibitors Withmulti-Site Binding Characteristics
J Ruan, K Lu, J He, Y Chen, B Li, X Wan, X Chen, S Li… - papers.ssrn.com
Emerging and potential influenza pandemics still are an enormous worldwide public health
challenge. The PAN endonuclease has been proved to be a promising target for anti …
challenge. The PAN endonuclease has been proved to be a promising target for anti …
[CITAAT][C] СИНТЕЗ КОНДЕНСОВАНИХ 1, 2, 4-ТІАДІАЗЕПІНІВ ТА 1, 2-ТІАЗЕПІНІВ НА ОСНОВІ АЛКІЛСУЛЬФОНАМІДІВ
ЮМ ВОЛОВЕНКО - 2023 - … національний університет імені …