Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

The origin of vertebrates was accompanied by the advent of a novel cell type: the neural
crest. Emerging from the central nervous system, these cells migrate to diverse locations and …

The cranial neural crest generates a huge diversity of derivatives, including the bulk of
connective and skeletal tissues of the vertebrate head. How neural crest cells acquire such …

The formation of the face and skull involves a complex series of developmental events
mediated by cells derived from the neural crest, endoderm, mesoderm, and ectoderm …

Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often
accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia …

Neural crest cells are a vertebrate-specific migratory, multipotent cell population that give
rise to a diverse array of cells and tissues during development. Cranial neural crest cells, in …

Plastin 3 (PLS3), a protein involved in the formation of filamentous actin (F-actin) bundles,
appears to be important in human bone health, on the basis of pathogenic variants in PLS3 …

Thyroid hormone (TH) regulates diverse developmental events and can drive disparate
cellular outcomes. In zebrafish, TH has opposite effects on neural crest derived pigment …

The arrangement and morphology of the vertebrate skull reflect functional and ecological
demands, making it a highly adaptable structure. However, the fundamental developmental …