Parkinson's disease: from synaptic loss to connectome dysfunction

A Bellucci, NB Mercuri, A Venneri… - Neuropathology and …, 2016 - Wiley Online Library
Parkinson's disease (PD) is a common neurodegenerative disorder with prominent loss of
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …

Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies

TT Lai, B Gericke, M Feja, M Conoscenti… - npj Parkinson's …, 2023 - nature.com
Synucleinopathies are neurodegenerative disorders characterized by alpha-synuclein
(αSyn) accumulation in neurons or glial cells, including Parkinson's disease (PD), dementia …

[HTML][HTML] Probiotics alleviate the progressive deterioration of motor functions in a mouse model of Parkinson's disease

TH Hsieh, CW Kuo, KH Hsieh, MJ Shieh, CW Peng… - Brain sciences, 2020 - mdpi.com
Parkinson's disease (PD) is one of the common long-term degenerative disorders that
primarily affect motor systems. Gastrointestinal (GI) symptoms are common in individuals …

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors

S Viana da Silva, MG Haberl, P Zhang, P Bethge… - Nature …, 2016 - nature.com
Synaptic plasticity in the autoassociative network of recurrent connections among
hippocampal CA3 pyramidal cells is thought to enable the storage of episodic memory …

Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson's disease: clues to early diagnosis and effective …

Y Bang, J Lim, HJ Choi - Archives of pharmacal research, 2021 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
movement dysfunction due to selective degeneration of dopaminergic neurons in the …

The neuroprotective effect of dimethyl fumarate in an MPTP-mouse model of Parkinson's disease: involvement of reactive oxygen species/nuclear factor-κB/nuclear …

M Campolo, G Casili, F Biundo, R Crupi… - Antioxidants & redox …, 2017 - liebertpub.com
Aim: Oxidative stress plays a key role in Parkinson disease (PD), and nuclear transcription
factor related to NF-E2 (Nrf-2) is involved in neuroprotection against PD. The aim of the …

Multitasking guardian of mitochondrial quality: Parkin function and Parkinson's disease

I Kamienieva, J Duszyński… - Translational …, 2021 - Springer
The familial form of Parkinson's disease (PD) is linked to mutations in specific genes. The
mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial …

Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease

J Keifer - Journal of neuroscience research, 2022 - Wiley Online Library
Research demonstrates that the neural mechanisms underlying synaptic plasticity and
learning and memory involve mobilization of AMPA‐type neurotransmitter receptors at …

High cholesterol diet exacerbates blood-brain barrier disruption in LDLr–/–mice: Impact on cognitive function

J de Oliveira, DF Engel, GC De Paula… - Journal of …, 2020 - content.iospress.com
Background: Evidence has revealed an association between familial hypercholesterolemia
and cognitive impairment. In this regard, a connection between cognitive deficits and …

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo

TG McWilliams, E Barini… - Royal Society …, 2018 - royalsocietypublishing.org
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell
culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and …