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Parkinson's disease: from synaptic loss to connectome dysfunction
A Bellucci, NB Mercuri, A Venneri… - Neuropathology and …, 2016 - Wiley Online Library
Parkinson's disease (PD) is a common neurodegenerative disorder with prominent loss of
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …
Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies
TT Lai, B Gericke, M Feja, M Conoscenti… - npj Parkinson's …, 2023 - nature.com
Synucleinopathies are neurodegenerative disorders characterized by alpha-synuclein
(αSyn) accumulation in neurons or glial cells, including Parkinson's disease (PD), dementia …
(αSyn) accumulation in neurons or glial cells, including Parkinson's disease (PD), dementia …
[HTML][HTML] Probiotics alleviate the progressive deterioration of motor functions in a mouse model of Parkinson's disease
Parkinson's disease (PD) is one of the common long-term degenerative disorders that
primarily affect motor systems. Gastrointestinal (GI) symptoms are common in individuals …
primarily affect motor systems. Gastrointestinal (GI) symptoms are common in individuals …
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors
Synaptic plasticity in the autoassociative network of recurrent connections among
hippocampal CA3 pyramidal cells is thought to enable the storage of episodic memory …
hippocampal CA3 pyramidal cells is thought to enable the storage of episodic memory …
Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson's disease: clues to early diagnosis and effective …
Y Bang, J Lim, HJ Choi - Archives of pharmacal research, 2021 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
movement dysfunction due to selective degeneration of dopaminergic neurons in the …
movement dysfunction due to selective degeneration of dopaminergic neurons in the …
The neuroprotective effect of dimethyl fumarate in an MPTP-mouse model of Parkinson's disease: involvement of reactive oxygen species/nuclear factor-κB/nuclear …
M Campolo, G Casili, F Biundo, R Crupi… - Antioxidants & redox …, 2017 - liebertpub.com
Aim: Oxidative stress plays a key role in Parkinson disease (PD), and nuclear transcription
factor related to NF-E2 (Nrf-2) is involved in neuroprotection against PD. The aim of the …
factor related to NF-E2 (Nrf-2) is involved in neuroprotection against PD. The aim of the …
Multitasking guardian of mitochondrial quality: Parkin function and Parkinson's disease
I Kamienieva, J Duszyński… - Translational …, 2021 - Springer
The familial form of Parkinson's disease (PD) is linked to mutations in specific genes. The
mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial …
mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial …
Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease
J Keifer - Journal of neuroscience research, 2022 - Wiley Online Library
Research demonstrates that the neural mechanisms underlying synaptic plasticity and
learning and memory involve mobilization of AMPA‐type neurotransmitter receptors at …
learning and memory involve mobilization of AMPA‐type neurotransmitter receptors at …
High cholesterol diet exacerbates blood-brain barrier disruption in LDLr–/–mice: Impact on cognitive function
Background: Evidence has revealed an association between familial hypercholesterolemia
and cognitive impairment. In this regard, a connection between cognitive deficits and …
and cognitive impairment. In this regard, a connection between cognitive deficits and …
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo
TG McWilliams, E Barini… - Royal Society …, 2018 - royalsocietypublishing.org
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell
culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and …
culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and …