The hitchhiker's guide to flow chemistry∥
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …
stream rather than in a flask. Flow equipment provides chemists with unique control over …
[HTML][HTML] Automating drug discovery
G Schneider - Nature reviews drug discovery, 2018 - nature.com
Small-molecule drug discovery can be viewed as a challenging multidimensional problem in
which various characteristics of compounds—including efficacy, pharmacokinetics and …
which various characteristics of compounds—including efficacy, pharmacokinetics and …
On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
Pharmaceutical manufacturing typically uses batch processing at multiple locations.
Disadvantages of this approach include long production times and the potential for supply …
Disadvantages of this approach include long production times and the potential for supply …
Taming hazardous chemistry by continuous flow technology
M Movsisyan, EIP Delbeke, J Berton… - Chemical Society …, 2016 - pubs.rsc.org
Over the last two decades, flow technologies have become increasingly popular in the field
of organic chemistry, offering solutions for engineering and/or chemical problems. Flow …
of organic chemistry, offering solutions for engineering and/or chemical problems. Flow …
Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …
millimeter region have found widespread application in organic synthesis. The characteristic …
Flow chemistry: recent developments in the synthesis of pharmaceutical products
R Porta, M Benaglia, A Puglisi - Organic Process Research & …, 2016 - ACS Publications
Recently, application of the flow technologies for the preparation of fine chemicals, such as
natural products or Active Pharmaceutical Ingredients (APIs), has become very popular …
natural products or Active Pharmaceutical Ingredients (APIs), has become very popular …
Multi-step continuous-flow synthesis
Organic chemistry is continually evolving to improve the syntheses of value added and
bioactive compounds. Through this progression, a concomitant advancement in laboratory …
bioactive compounds. Through this progression, a concomitant advancement in laboratory …
C–H functionalization of azines
Azines, which are six-membered aromatic compounds containing one or more nitrogen
atoms, serve as ubiquitous structural cores of aromatic species with important applications in …
atoms, serve as ubiquitous structural cores of aromatic species with important applications in …
Towards the standardization of flow chemistry protocols for organic reactions
Flow chemistry studies can sometimes be difficult to reproduce. In this article we provide
guidance to scientists for experimental details that should be considered as part of any …
guidance to scientists for experimental details that should be considered as part of any …
Organic synthesis: march of the machines
SV Ley, DE Fitzpatrick, RJ Ingham… - Angewandte Chemie …, 2015 - Wiley Online Library
Organic synthesis is changing; in a world where budgets are constrained and the
environmental impacts of practice are scrutinized, it is increasingly recognized that the …
environmental impacts of practice are scrutinized, it is increasingly recognized that the …