Although promising therapeutics are in the pipeline, bariatric surgery (also known as
metabolic surgery) remains our most effective strategy for the treatment of obesity and type 2 …

Insulin is a life-saving drug for patients with type 1 diabetes; however, even today, no
pharmacotherapy can prevent the loss or dysfunction of pancreatic insulin-producing β cells …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

Hyperglucagonemia has been implicated in the pathogenesis of type 2 diabetes (T2D). In
contrast to β-cells, studies on the function of the pancreatic α-cell in T2D are scarce …

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia and
impaired islet secretion that places a heavy burden on the global health care system due to …

Pancreatic β-cell function impairment and insulin resistance are central to the development
of obesity-related type 2 diabetes mellitus (T2DM). Bariatric surgery (BS) is a practical …

Vertical sleeve gastrectomy (VSG) restores glucose homeostasis in obese mice and
humans. In addition, the increased fibroblast growth factor (FGF) 15/19 circulating level …

Background Response to metabolic surgery is heterogeneous and the metabolic states that
underpin weight loss and metabolic improvement are still unclear. In this study, we …

Body contouring surgery enhances physical appearance by means of surgical
subcutaneous fat removal (SSFR). However, it remains unclear how SSFR may affect …

Context Bariatric surgery has been shown to be effective in inducing complete remission of
type 2 diabetes in adults with obesity. However, its efficacy in achieving complete diabetes …