Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda
A Uwimana, E Legrand, BH Stokes, JLM Ndikumana… - Nature medicine, 2020 - nature.com
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based
combination therapy), is widespread across Southeast Asia but to date has not been …
combination therapy), is widespread across Southeast Asia but to date has not been …
[BOOK][B] World malaria report 2023
World Health Organization - 2023 - books.google.com
Page 1 World malaria וייוייו report 2023 wwwwww World Health Organization Page 2 World
malaria report 2023 ISBN 978-92-4-008617-3 (electronic version) ISBN 978-92-4-008618-0 …
malaria report 2023 ISBN 978-92-4-008617-3 (electronic version) ISBN 978-92-4-008618-0 …
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …
falciparum malaria parasites has led to widespread treatment failures across Southeast …
Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival
The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium
falciparum K13, has compromised antimalarial efficacy and threatens the global malaria …
falciparum K13, has compromised antimalarial efficacy and threatens the global malaria …
Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …
important infectious diseases in the world. Standard treatment for uncomplicated P …
[HTML][HTML] Plasmodium falciparum resistance to artemisinin-based combination therapies
Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …
Artemisinin-resistant malaria
NJ White, K Chotivanich - Clinical Microbiology Reviews, 2024 - journals.asm.org
The artemisinin antimalarials are the cornerstone of current malaria treatment. The
development of artemisinin resistance in Plasmodium falciparum poses a major threat to …
development of artemisinin resistance in Plasmodium falciparum poses a major threat to …
Triple artemisinin-based combination therapies for malaria–a new paradigm?
RW van der Pluijm, C Amaratunga, M Dhorda… - Trends in …, 2021 - cell.com
Recent gains in the fight against malaria are threatened by the emergence and spread of
artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong …
artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong …