The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma
L Liu, M Gu, J Ma, Y Wang, M Li, H Wang, X Yin, X Li - Molecular cancer, 2022 - Springer
Background Emerging evidence indicates that circular RNAs (circRNAs) and m6A RNA
methylation participate in the pathogenesis and metastasis of multiple malignancies …
methylation participate in the pathogenesis and metastasis of multiple malignancies …
FTO in cancer: functions, molecular mechanisms, and therapeutic implications
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance
Q Lan, PY Liu, JL Bell, JY Wang, S Hüttelmaier… - Cancer research, 2021 - AACR
Abstract RNA N6-methyladenosine (m6A) modification occurs in approximately 25% of
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A …
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A …
FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner
J Huang, W Sun, Z Wang, C Lv, T Zhang… - Journal of Experimental …, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most common chemical
modification in mammalian mRNAs, and it plays important roles by regulating several …
modification in mammalian mRNAs, and it plays important roles by regulating several …
Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation
B Ou, Y Liu, Z Gao, J Xu, Y Yan, Y Li, J Zhang - Cell death & disease, 2022 - nature.com
Cellular senescence is characterized by a tumor-suppressive program as well as a pro-
inflammatory secretome. Neutrophils constitute significant compositions of malignancies and …
inflammatory secretome. Neutrophils constitute significant compositions of malignancies and …
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis
DY Ruan, T Li, YN Wang, Q Meng, Y Li, K Yu, M Wang… - Oncogene, 2021 - nature.com
Fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m6A)
demethylase, participates in tumor progression and metastasis in many malignancies, but its …
demethylase, participates in tumor progression and metastasis in many malignancies, but its …
The m6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the …
Y Zhang, X Liu, Y Wang, S Lai, Z Wang, Y Yang, W Liu… - Molecular cancer, 2022 - Springer
Background Chemoresistance is a major factor contributing to the poor prognosis of patients
with pancreatic cancer, and cancer stemness is one of the most crucial factors associated …
with pancreatic cancer, and cancer stemness is one of the most crucial factors associated …