Three of the four currently approved drugs for the treatment of African trypanosomiasis
(slee** sickness) were developed over 50 years ago. All of the current therapies are …

This review discusses the challenges of chemotherapy for human African trypanosomiasis
(HAT). The few drugs registered for use against the disease are unsatisfactory for a number …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

Despite the many decades of use of most of the current trypanocides, we know little of their
mode of action. This may in part be because most of these will act on multiple targets once …

Diamidines, and pentamidine in particular, have a long history as valuable
chemotherapeutic agents against infectious disease. Their selectivity is due mostly to …

The family Trypanosomatidae, flagellated parasitic protozoa, is responsible for important
infectious diseases in humans: slee** sickness, Chagas diseases and leishmaniasis …

African trypanosomes cause slee** sickness in humans, a disease that is typically fatal
without chemotherapy. Unfortunately, drug resistance is common and melarsoprol-resistant …

The African trypanosome, Trypanosoma brucei brucei, possesses at least two nucleoside
transporter systems designated P1 and P2, the latter being implicated in the selective uptake …

The uptake of [3H] pentamidine into wild-type and drug-resistant strains of Leishmania
mexicana was compared. Uptake was carrier mediated. Pentamidine-resistant parasites …

Drug resistance in pathogenic trypanosomes threatens successful control of fatal slee**
sickness in man and hinders economic livestock production in sub-Saharan Africa. We …