This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

In recent decades, self-confinement effects arising from the folding of individual synthetic
polymer chains to single-chain nanoparticles (SCNPs) have been exploited for the …

Multicyclic peptides with stable 3D structures are a kind of novel and promising peptide
formats for drug design and discovery as they have the potential to combine the best …

Cyclotides are plant-derived peptides with complex structures shaped by their head-to-tail
cyclic backbone and cystine knot core. These structural features underpin the native …

Covering: 1992 up to 2023 Since their discovery, lasso peptides went from peculiarities to
be recognized as a major family of ribosomally synthesized and post-translationally modified …

The engineering of naturally occurring disulfide-rich peptides (DRPs) has been significantly
hampered by the difficulty of manipulating disulfide pairing. New DRPs that take advantage …

Peptides are valuable for therapeutic development, with multicyclic peptides showing
promise in mimicking antigen-binding potency of antibodies. However, our capability to …

Conspectus The precision design of topologically intriguing macromolecular architectures
has continuously been an attractive challenge in polymer science and polymer materials …

Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality, and it has three major pathogeneses, namely alveolar–capillary barrier …

Sulfilimines, a privileged class of–S (IV) N–functional groups found in nature, have been
exploited as valuable building blocks in organic synthesis and as pharmacophores in drug …