The N‐end rule pathway and regulation by proteolysis
A Varshavsky - Protein science, 2011 - Wiley Online Library
The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …
AAA+ proteases: ATP-fueled machines of protein destruction
RT Sauer, TA Baker - Annual review of biochemistry, 2011 - annualreviews.org
AAA+ family proteolytic machines (ClpXP, ClpAP, ClpCP, HslUV, Lon, FtsH, PAN/20S, and
the 26S proteasome) perform protein quality control and are used in regulatory circuits in all …
the 26S proteasome) perform protein quality control and are used in regulatory circuits in all …
The N-end rule pathway
The N-end rule pathway is a proteolytic system in which N-terminal residues of short-lived
proteins are recognized by recognition components (N-recognins) as essential components …
proteins are recognized by recognition components (N-recognins) as essential components …
Directed evolution of material-producing microorganisms
Nature is home to a variety of microorganisms that create materials under environmentally
friendly conditions. While this offers an attractive approach for sustainable manufacturing …
friendly conditions. While this offers an attractive approach for sustainable manufacturing …
Proteolysis in bacterial regulatory circuits
S Gottesman - Annual review of cell and developmental biology, 2003 - annualreviews.org
▪ Abstract Proteolysis by cytoplasmic, energy-dependent proteases plays a critical role in
many regulatory circuits, kee** basal levels of regulatory proteins low and rapidly …
many regulatory circuits, kee** basal levels of regulatory proteins low and rapidly …
A structure‐based benchmark for protein–protein binding affinity
We have assembled a nonredundant set of 144 protein–protein complexes that have high‐
resolution structures available for both the complexes and their unbound components, and …
resolution structures available for both the complexes and their unbound components, and …
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases
Members of the AAA+ protein superfamily contribute to many diverse aspects of protein
homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic …
homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic …
Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)
Abstract Johanson-Blizzard syndrome (OMIM 243800) is an autosomal recessive disorder
that includes congenital exocrine pancreatic insufficiency, multiple malformations such as …
that includes congenital exocrine pancreatic insufficiency, multiple malformations such as …
The N-end rule pathway: emerging functions and molecular principles of substrate recognition
SM Sriram, BY Kim, YT Kwon - Nature reviews Molecular cell biology, 2011 - nature.com
The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue
and its post-translational modification. Since its discovery 25 years ago, the pathway …
and its post-translational modification. Since its discovery 25 years ago, the pathway …
Chloroplast proteases: updates on proteolysis within and across suborganellar compartments
Chloroplasts originated from the endosymbiosis of ancestral cyanobacteria and maintain
transcription and translation machineries for around 100 proteins. Most endosymbiont …
transcription and translation machineries for around 100 proteins. Most endosymbiont …