Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …

Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …

Structural polymers are susceptible to damage in the form of cracks, which form deep within
the structure where detection is difficult and repair is almost impossible. Cracking leads to …

During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …

The nuclear hormone receptor superfamily includes receptors for thyroid and steroid
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …

Nuclear receptors (NR) comprise a family of transcription factors that regulate gene
expression in a liganddependent manner. Members of the NR superfamily include receptors …

The last few years have witnessed a rapid increase in our knowledge of the retinoid-related
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …

Many cofactors bind the hormone-activated estrogen receptor (ER), yet the specific
regulators of endogenous ER-mediated gene transcription are unknown. Using chromatin …

The inflammatory response is a highly regulated physiological process that is critically
important for homeostasis. A precise physiological control of inflammation allows a timely …

Deaths from breast cancer have fallen markedly over the past decade due, in part, to the use
of endocrine agents that reduce the levels of circulating oestrogens or compete with …