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Inference and applications of ancestral recombination graphs
Ancestral recombination graphs (ARGs) summarize the complex genealogical relationships
between individuals represented in a sample of DNA sequences. Their use is currently …
between individuals represented in a sample of DNA sequences. Their use is currently …
Thinking about the evolution of complex traits in the era of genome-wide association studies
Many traits of interest are highly heritable and genetically complex, meaning that much of
the variation they exhibit arises from differences at numerous loci in the genome. Complex …
the variation they exhibit arises from differences at numerous loci in the genome. Complex …
Variable prediction accuracy of polygenic scores within an ancestry group
Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …
based on genome-wide association studies (GWAS) for phenotypic prediction. However …
A method for genome-wide genealogy estimation for thousands of samples
Abstract Knowledge of genome-wide genealogies for thousands of individuals would
simplify most evolutionary analyses for humans and other species, but has remained …
simplify most evolutionary analyses for humans and other species, but has remained …
The promise of inferring the past using the ancestral recombination graph
The ancestral recombination graph (ARG) is a structure that represents the history of
coalescent and recombination events connecting a set of sequences (Hudson RR. In …
coalescent and recombination events connecting a set of sequences (Hudson RR. In …
An approximate full-likelihood method for inferring selection and allele frequency trajectories from DNA sequence data
Most current methods for detecting natural selection from DNA sequence data are limited in
that they are either based on summary statistics or a composite likelihood, and as a …
that they are either based on summary statistics or a composite likelihood, and as a …
Landmarks in the history of selective sweeps
Half a century ago, a seminal article on the hitchhiking effect by Smith and Haigh
inaugurated the concept of the selection signature. Selective sweeps are characterised by …
inaugurated the concept of the selection signature. Selective sweeps are characterised by …
[HTML][HTML] Recent positive selection signatures reveal phenotypic evolution in the Han Chinese population
Characterizing natural selection signatures and relationships with phenotype spectra is
important for understanding human evolution and both biological and pathological …
important for understanding human evolution and both biological and pathological …
Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies
We present a full-likelihood method to infer polygenic adaptation from DNA sequence
variation and GWAS summary statistics to quantify recent transient directional selection …
variation and GWAS summary statistics to quantify recent transient directional selection …
Polygenic adaptation after a sudden change in environment
Polygenic adaptation is thought to be ubiquitous, yet remains poorly understood. Here, we
model this process analytically, in the plausible setting of a highly polygenic, quantitative …
model this process analytically, in the plausible setting of a highly polygenic, quantitative …