Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a
technological breakthrough in the diagnosis, treatment, and follow-up of many retinal …

Studies utilizing large animal models of inherited retinal degeneration (IRD) have proven
important in not only the development of translational therapeutic approaches, but also in …

The retina is a very fine and layered neural tissue, which vitally depends on the preservation
of cells, structure, connectivity and vasculature to maintain vision. There is an urgent need to …

To develop biological approaches to restore vision, we developed a method of transplanting
stem cell-derived retinal tissue into the subretinal space of a large-eye animal model (cat) …

In this study, we investigate a gene augmentation therapy candidate for the treatment of
retinitis pigmentosa (RP) due to cyclic nucleotide-gated channel beta 1 (CNGB1) mutations …

The vertebrate retina is made up of six specialized neuronal cell types and one glia that are
generated from a common retinal progenitor. The development of these distinct cell types is …

Mutations in the phosphodiesterase 6A gene (PDE6A) result in retinitis pigmentosa (RP)
type 43 (RP43) and are responsible for about 4% of autosomal recessive RP. There is …

Spontaneously occurring animal models of retinal disease and genetically manipulated
mice have been an important resource not only to test gene therapies, but also to discover …

Pathogenic variants in retinol dehydrogenase 5 (RDH5) attenuate supply of 11-cis-retinal to
photoreceptors leading to a range of clinical phenotypes including night blindness because …

Dysfunction and death of retinal pigment epithelium (RPE) and or photoreceptors can lead
to irreversible vision loss. The eye represents an ideal microenvironment for stem cell …