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Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
Abstract AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic
glutamate receptors mediate fast excitatory neurotransmission throughout the central …
glutamate receptors mediate fast excitatory neurotransmission throughout the central …
The cell biology of synaptic plasticity: AMPA receptor trafficking
The cellular processes that govern neuronal function are highly complex, with many basic
cell biological pathways uniquely adapted to perform the elaborate information processing …
cell biological pathways uniquely adapted to perform the elaborate information processing …
Regulatory mechanisms of AMPA receptors in synaptic plasticity
VA Derkach, MC Oh, ES Guire… - Nature Reviews …, 2007 - nature.com
Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism
for the plasticity of neuronal networks that is widely recognized to underlie cognitive …
for the plasticity of neuronal networks that is widely recognized to underlie cognitive …
[HTML][HTML] The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits
AC Jackson, RA Nicoll - Neuron, 2011 - cell.com
Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …
[HTML][HTML] Opening of glutamate receptor channel to subconductance levels
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that open
their pores in response to binding of the agonist glutamate,–. An ionic current through a …
their pores in response to binding of the agonist glutamate,–. An ionic current through a …
Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor
AMPA glutamate receptors (AMPARs), the primary mediators of excitatory
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
Stargazin modulates AMPA receptor gating and trafficking by distinct domains
Abstract AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors mediate
fast excitatory synaptic transmission in the brain. These ion channels rapidly deactivate and …
fast excitatory synaptic transmission in the brain. These ion channels rapidly deactivate and …