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The complexity of the Nrf2 pathway: beyond the antioxidant response
The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an
efficient and pivotal line of defensive to counteract environmental insults and endogenous …
efficient and pivotal line of defensive to counteract environmental insults and endogenous …
Indoles derived from glucobrassicin: cancer chemoprevention by indole-3-carbinol and 3, 3'-diindolylmethane
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles
predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3, 3' …
predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3, 3' …
Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
Luteolin, a dietary flavone, modulates various signaling pathways involved in
carcinogenesis. In this study, we investigated the molecular mechanism that underlies the …
carcinogenesis. In this study, we investigated the molecular mechanism that underlies the …
Anticancer activity of sulforaphane: the epigenetic mechanisms and the Nrf2 signaling pathway
Sulforaphane (SFN), a compound derived from cruciferous vegetables that has been shown
to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its …
to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its …
Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals
Keap1/Nrf2 system plays a critical role on cellular protection by regulating many antioxidant
and detoxification enzyme genes through the antioxidant response element (ARE). Thus, it …
and detoxification enzyme genes through the antioxidant response element (ARE). Thus, it …
Epigenetic regulation of Keap1-Nrf2 signaling
The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2
(Nrf2) signaling axis serves as a “master regulator” in response to oxidative/electrophilic …
(Nrf2) signaling axis serves as a “master regulator” in response to oxidative/electrophilic …
Mechanisms underlying biological effects of cruciferous glucosinolate-derived isothiocyanates/indoles: a focus on metabolic syndrome
An inverse correlation between vegetable consumption and the incidence of cancer has
long been described. This protective effect is stronger when cruciferous vegetables are …
long been described. This protective effect is stronger when cruciferous vegetables are …
Dietary glucosinolates sulforaphane, phenethyl isothiocyanate, indole-3-carbinol/3, 3′-diindolylmethane: Antioxidative stress/inflammation, Nrf2, epigenetics …
Glucosinolates are a group of sulfur-containing glycosides found in many plant species,
including cruciferous vegetables such as broccoli, cabbage, Brussels sprouts, and …
including cruciferous vegetables such as broccoli, cabbage, Brussels sprouts, and …
[HTML][HTML] Natural bioactive compounds targeting epigenetic pathways in cancer: a review on alkaloids, terpenoids, quinones, and isothiocyanates
Cancer is one of the most complex and systemic diseases affecting the health of mankind,
causing major deaths with a significant increase. This pathology is caused by several risk …
causing major deaths with a significant increase. This pathology is caused by several risk …
NRF2 modulation in TRAMP mice: An in vivo model of prostate cancer
Abstract Background Prostate cancer (PCa) is one of the most common cancers worldwide
and oxidative stress is involved in its occurrence, development and progression. In fact, in …
and oxidative stress is involved in its occurrence, development and progression. In fact, in …