Cytokine storm in COVID-19: the current evidence and treatment strategies
Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes
coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has …
coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has …
Overview of immune response during SARS-CoV-2 infection: lessons from the past
After the 1918 flu pandemic, the world is again facing a similar situation. However, the
advancement in medical science has made it possible to identify that the novel infectious …
advancement in medical science has made it possible to identify that the novel infectious …
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—a new coronavirus that
has led to a worldwide pandemic—has a furin cleavage site (PRRAR) in its spike protein …
has led to a worldwide pandemic—has a furin cleavage site (PRRAR) in its spike protein …
[HTML][HTML] SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract
The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …
Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection
Identification of host genes essential for severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection may reveal novel therapeutic targets and inform our understanding …
(SARS-CoV-2) infection may reveal novel therapeutic targets and inform our understanding …
[HTML][HTML] Why does COVID-19 disproportionately affect older people?
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
[HTML][HTML] Type I and type III interferons–induction, signaling, evasion, and application to combat COVID-19
A Park, A Iwasaki - Cell host & microbe, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics …
respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics …
Interplay between SARS-CoV-2 and the type I interferon response
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …
[HTML][HTML] Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2-mediated interferon responses and pneumocyte dysfunction
Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …