Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

How do antidepressants elicit an antidepressant response? Here, we review accumulating
evidence that the neurotrophin brain-derived neurotrophic factor (BDNF) serves as a …

Fear memory is the best-studied form of memory. It was thoroughly investigated in the past
60 years mostly using two classical conditioning procedures (contextual fear conditioning …

Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,
where proteins, lipids, and organelles are degraded and recycled. According to the way the …

Emerging findings suggest that brain-derived neurotrophic factor (BDNF) serves widespread
roles in regulating energy homeostasis by controlling patterns of feeding and physical …

Background: Recent studies demonstrate that the rapid antidepressant ketamine increases
spine number and function in the medial prefrontal cortex (mPFC), and that these effects are …

Mammalian target of rapamycin (mTOR) is a protein kinase involved in translation control
and long-lasting synaptic plasticity. mTOR functions as the central component of two multi …

Since its discovery almost three decades ago, the secreted neurotrophin brain-derived
neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of …

Currently available medications have significant limitations, most notably low response rate
and time lag for treatment response. Recent clinical studies have demonstrated that …