Infectious and inflammatory pathways to cough

KF Naqvi, SB Mazzone… - Annual review of …, 2023 - annualreviews.org
Coughing is a dynamic physiological process resulting from input of vagal sensory neurons
innervating the airways and perceived airway irritation. Although cough serves to protect …

The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model

J Holubova, O Stanek, A Juhasz… - PLoS …, 2022 - journals.plos.org
Pulmonary infections caused by Bordetella pertussis used to be the prime cause of infant
mortality in the pre-vaccine era and mouse models of pertussis pneumonia served in …

Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge

KL Weaver, GJ Bitzer, MA Wolf, GM Pyles, MA DeJong… - Plos one, 2023 - journals.plos.org
The murine Bordetella pertussis challenge model has been utilized in preclinical research
for decades. Currently, inconsistent methodologies are employed by researchers across the …

Immunization with an mRNA DTP vaccine protects against pertussis in rats

GJ Bitzer, NA Fitzgerald, MA DeJong… - Infection and …, 2024 - journals.asm.org
Bordetella pertussis is a Gram-negative bacterium that is the causative agent of the
respiratory disease known as pertussis. Since the switch to the acellular vaccines of DTaP …

The mechanism of pertussis cough revealed by the mouse-coughing model

Y Hiramatsu, K Suzuki, T Nishida, N Onoda, T Satoh… - Mbio, 2022 - Am Soc Microbiol
Pertussis, also known as whoo** cough, is a contagious respiratory disease caused by
the Gram-negative bacterium Bordetella pertussis. This disease is characterized by severe …

Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice

MA Wolf, JM O'Hara, GJ Bitzer, E Narayanan… - npj Vaccines, 2024 - nature.com
Acellular multivalent vaccines for pertussis (DTaP and Tdap) prevent symptomatic disease
and infant mortality, but immunity to Bordetella pertussis infection wanes significantly over …

Long-Term Analysis of Pertussis Vaccine Immunity to Identify Potential Markers of Vaccine-Induced Memory Associated With Whole Cell But Not Acellular Pertussis …

KL Weaver, CB Blackwood, AM Horspool… - Frontiers in …, 2022 - frontiersin.org
Over two decades ago acellular pertussis vaccines (aP) replaced whole cell pertussis
vaccines (wP) in several countries. Since then, a resurgence in pertussis has been …

Mucosal Vaccination with Live Attenuated Bordetella bronchiseptica Protects against Challenge in Wistar Rats

BM Chamorro, KD Luca, G Swaminathan… - Vaccines, 2023 - mdpi.com
Bordetella bronchiseptica (Bb) is a Gram-negative bacterium responsible for canine
infectious respiratory disease complex (CIRDC). Several vaccines targeting this pathogen …

Mucosal Immunization with DTaP Confers Protection against Bordetella pertussis Infection and Cough in Sprague-Dawley Rats

JM Hall, GJ Bitzer, MA DeJong, J Kang… - Infection and …, 2021 - Am Soc Microbiol
Pertussis is a respiratory disease caused by the Gram-negative pathogen, Bordetella
pertussis. The transition from a whole-cell pertussis vaccine (wP and DTP) to an acellular …

Current understanding of Bordetella‐induced cough

Y Horiguchi - Microbiology and Immunology, 2024 - Wiley Online Library
Typical pathogenic bacteria of the genus Bordetella cause respiratory diseases, many of
which are characterized by severe coughing in host animals. In human infections with these …