Anticancer thiosemicarbazones: chemical properties, interaction with iron metabolism, and resistance development
FS PapeVeronika, A EnyedyÉva… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …
Metal complexes of thiosemicarbazones for imaging and therapy
JR Dilworth, R Hueting - Inorganica Chimica Acta, 2012 - Elsevier
This review gives an account of the coordination chemistry of thiosemicarbazone ligands
with three (tridentate) or four (tetradentate) potential donor atoms. The syntheses and …
with three (tridentate) or four (tetradentate) potential donor atoms. The syntheses and …
New water-soluble copper (II) complexes with morpholine–thiosemicarbazone hybrids: Insights into the anticancer and antibacterial mode of action
K Ohui, E Afanasenko, F Bacher, RLX Ting… - Journal of medicinal …, 2018 - ACS Publications
Six morpholine-(iso) thiosemicarbazone hybrids HL 1–HL 6 and their Cu (II) complexes with
good-to-moderate solubility and stability in water were synthesized and characterized. Cu …
good-to-moderate solubility and stability in water were synthesized and characterized. Cu …
Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities
C Zhang, F Zhang - Protein & cell, 2015 - academic.oup.com
Excess iron is tightly associated with tumorigenesis in multiple human cancer types through
a variety of mechanisms including catalyzing the formation of mutagenic hydroxyl radicals …
a variety of mechanisms including catalyzing the formation of mutagenic hydroxyl radicals …
Thiosemicarbazone derivatives developed to overcome COTI-2 resistance
Simple Summary Besides zinc, also iron and copper need to be considered to play a role in
the mode of action and resistance development of the anticancer thiosemicarbazone COTI-2 …
the mode of action and resistance development of the anticancer thiosemicarbazone COTI-2 …
Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and …
A Popović-Bijelić, CR Kowol, MES Lind, J Luo… - Journal of inorganic …, 2011 - Elsevier
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone, 3-AP) is currently the most
promising chemotherapeutic compound among the class of α-N-heterocyclic …
promising chemotherapeutic compound among the class of α-N-heterocyclic …
Gallium complexes as new promising metallodrug candidates
JA Lessa, GL Parrilha, H Beraldo - Inorganica Chimica Acta, 2012 - Elsevier
This is a review article on non-radioactive gallium (III) complexes as new promising metal-
based drug candidates. A great variety of gallium (III) complexes and their pharmacological …
based drug candidates. A great variety of gallium (III) complexes and their pharmacological …
α− N− heterocyclic thiosemicarbazone Fe (III) complex: Characterization of its antitumor activity and identification of anticancer mechanism
Y Gou, J Wang, S Chen, Z Zhang, Y Zhang… - European Journal of …, 2016 - Elsevier
We synthesized an α− N− heterocyclic thiosemicarbazone ligand (L) and its Fe complex
(C1) and assessed their chemical and biological properties in order to understand their …
(C1) and assessed their chemical and biological properties in order to understand their …
Reactivity of Cu(ii)–, Zn(ii)– and Fe(ii)–thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation
Thiosemicarbazones (TSCs) are a class of strong metal ion ligands, which are currently
being investigated for several applications, such as anticancer treatment. In addition to these …
being investigated for several applications, such as anticancer treatment. In addition to these …
High copper complex stability and slow reduction kinetics as key parameters for improved activity, paraptosis induction, and impact on drug-resistant cells of …
Aims: Due to their significant biological activity, thiosemicarbazones (TSCs) are promising
candidates for anticancer therapy. In part, the efficacy of TSCs is linked to their ability to …
candidates for anticancer therapy. In part, the efficacy of TSCs is linked to their ability to …