Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing
compounds in modern technology and daily life, the explosive development of the …

Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery,
agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s …

The concept of functional groups (FGs), sets of connected atoms that can determine the
intrinsic reactivity of the parent molecule and in part are responsible for the overall …

The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

There is a growing interest in organic compounds containing the difluoromethyl group, as it
is considered a lipophilic hydrogen bond donor that may act as a bioisostere of hydroxyl …

Fluorine, often called as “a small atom with a big ego”, 1 lies in the second row and the 17th
column in the periodic table of the chemical elements. This unique position in the periodic …

The review covers various aspects of fluorinated cycloalkyl (C3− C7) building blocks for drug
discovery, including their synthesis, key physicochemical properties, and biological and …

Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal
chemistry has become commonplace, with the small electronegative fluorine atom being a …

Physico‐chemical properties important to drug discovery (pKa, LogP, and aqueous
solubility), as well as metabolic stability, were studied for a series of functionalized gem …

We previously reported the design of spirooxindoles with two identical substituents at the
carbon-2 of the pyrrolidine core as potent MDM2 inhibitors. In this paper we describe an …