The mammalian nervous system is comprised of a seemingly infinitely complex network of
specialized synaptic connections that coordinate the flow of information through it. The field …

The exquisite intricacies of neural circuits are fundamental to an animal's diverse and
complex repertoire of sensory and motor functions. The ability to precisely map neural …

Changed synapse density has been suggested to be involved in the altered brain
connectivity underlying schizophrenia (SCZ) pathology. However, postmortem studies …

Oncogenes can initiate tumors only in certain cellular contexts, which is referred to as
oncogenic competence. In melanoma, whether cells in the microenvironment can endow …

Vesicular release from neurons promotes myelin sheath growth on axons. Oligodendrocytes
express proteins that allow dendrites to respond to vesicular release at synapses …

Using electron microscopy to localize rare cellular events or structures in complex tissue is
challenging. Correlative light and electron microscopy procedures have been developed to …

A major aim in structural cell biology is to analyze intact cells in three dimensions, visualize
subcellular structures, and even localize proteins at the best possible resolution in three …

Neurons receive a large number of active synaptic inputs from their many presynaptic
partners across their dendritic tree. However, little is known about how the strengths of …

Motivation Synapses are essential to neural signal transmission. Therefore, quantification of
synapses and related neurites from images is vital to gain insights into the underlying …

Dendrites are crucial for integrating incoming synaptic information. Individual dendritic
branches are thought to constitute a signal processing unit, yet how neighboring synapses …