Enhancing CNS mitophagy: drug development and disease-relevant models
KS Dhar, B Townsend, AP Montgomery… - Trends in …, 2024 - cell.com
Mitophagy, the selective degradation of mitochondria, is impaired in many
neurodegenerative diseases (NDs), resulting in an accumulation of dysfunctional …
neurodegenerative diseases (NDs), resulting in an accumulation of dysfunctional …
[HTML][HTML] Coordinating BNIP3/NIX-mediated mitophagy in space and time
Mitochondria maintain organellar homeostasis through multiple quality control pathways,
including the clearance of defective or unwanted mitochondria by selective autophagy. This …
including the clearance of defective or unwanted mitochondria by selective autophagy. This …
Dual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX
PPTC7 is a mitochondrial-localized phosphatase that suppresses BNIP3-and NIX-mediated
mitophagy, but the mechanisms underlying this regulation remain ill-defined. Here, we …
mitophagy, but the mechanisms underlying this regulation remain ill-defined. Here, we …
Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery
E Adriaenssens, S Schaar, ASI Cook, JFM Stuke… - …, 2024 - pmc.ncbi.nlm.nih.gov
Selective autophagy is a lysosomal degradation pathway that is critical for maintaining
cellular homeostasis by disposing of harmful cellular material. While the mechanisms by …
cellular homeostasis by disposing of harmful cellular material. While the mechanisms by …
Sex and Region-Specific Disruption of Autophagy and Mitophagy in Alzheimer's Disease: Linking Cellular Dysfunction to Cognitive Decline
Macroautophagy and mitophagy are critical processes in Alzheimer disease (AD), yet their
links to behavioral outcomes, particularly sex-specific differences, are not fully understood …
links to behavioral outcomes, particularly sex-specific differences, are not fully understood …