Mechanistic insights into the basis of widespread RNA localization
M Chekulaeva - Nature Cell Biology, 2024 - nature.com
The importance of subcellular mRNA localization is well established, but the underlying
mechanisms mostly remain an enigma. Early studies suggested that specific mRNA …
mechanisms mostly remain an enigma. Early studies suggested that specific mRNA …
Massively parallel identification of mRNA localization elements in primary cortical neurons
S Mendonsa, N von Kügelgen, S Dantsuji, M Ron… - Nature …, 2023 - nature.com
Cells adopt highly polarized shapes and form distinct subcellular compartments in many
cases due to the localization of many mRNAs to specific areas, where they are translated …
cases due to the localization of many mRNAs to specific areas, where they are translated …
Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer
Q Sun, Y Han, J He, J Wang, X Ma, Q Ning, Q Zhao… - Genome Medicine, 2023 - Springer
Background Alternative splicing complexity plays a vital role in carcinogenesis and cancer
progression. Improved understanding of novel splicing events and the underlying regulatory …
progression. Improved understanding of novel splicing events and the underlying regulatory …
Advancements in medical diagnosis and treatment through machine learning: A review
The aptness of machine learning (ML) to learn from large datasets, discover trends, and
make predictions has demonstrated its potential to metamorphose the medical field. Medical …
make predictions has demonstrated its potential to metamorphose the medical field. Medical …
CDK11 requires a critical activator SAP30BP to regulate pre‐mRNA splicing
C Wang, L Xu, C Du, H Yun, K Wang, H Liu, M Ye… - The EMBO …, 2023 - embopress.org
CDK11 is an emerging druggable target for cancer therapy due to its prevalent roles in
phosphorylating critical transcription and splicing factors and in facilitating cell cycle …
phosphorylating critical transcription and splicing factors and in facilitating cell cycle …
Transcriptomic analysis reveals regulation of adipogenesis via long non-coding RNA, alternative splicing, and alternative polyadenylation
Obesity is characterized by dysregulated adipogenesis that leads to increased number
and/or size of adipocytes. Understanding the molecular mechanisms governing …
and/or size of adipocytes. Understanding the molecular mechanisms governing …
Demonstration of the pathogenicity of a common non-exomic mutation in ABCA4 using iPSC-derived retinal organoids and retrospective clinical data
Mutations in ABCA4 are the most common cause of Mendelian retinal disease. Clinical
evaluation of this gene is challenging because of its extreme allelic diversity, the large …
evaluation of this gene is challenging because of its extreme allelic diversity, the large …
Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response
MR Murphy, A Ramadei, A Doymaz… - Nucleic Acids …, 2023 - academic.oup.com
Alternative Polyadenylation (APA) is an emerging mechanism for dynamic changes in gene
expression. Previously, we described widespread APA occurrence in introns during the DNA …
expression. Previously, we described widespread APA occurrence in introns during the DNA …
[HTML][HTML] MAPKAPK2-centric transcriptome profiling reveals its major role in governing molecular crosstalk of IGFBP2, MUC4, and PRKAR2B during HNSCC …
Transcriptome analysis of head and neck squamous cell carcinoma (HNSCC) has been
pivotal to comprehending the convoluted biology of HNSCC tumors. MAPKAPK2 or MK2 is a …
pivotal to comprehending the convoluted biology of HNSCC tumors. MAPKAPK2 or MK2 is a …
Impact of the RNA allosteric effect triggered by single nucleotide polymorphisms on the splicing process
Y Zhuang, X Lu, P Lin, S Wang, X Sheng… - Human Molecular …, 2023 - academic.oup.com
The susceptibility single nucleotide polymorphisms (SNPs) obtained by genome-wide
association studies leave some thorny questions, such as prioritization, false positives and …
association studies leave some thorny questions, such as prioritization, false positives and …