The medical and pharmaceutical communities are facing a dire need for new druggable
targets, while, paradoxically, the targets of some drugs that are in clinical use or …

Small-molecule inhibitors of protein and lipid kinases have emerged as indispensable tools
for studying signal transduction. Despite the widespread use of these reagents, there is little …

Lung cancers are the leading cause of cancer-related mortality worldwide, and the majority
of lung cancers are non–small cell lung carcinoma (NSCLC). Overexpressed or activated …

We have previously examined the specificities of 28 commercially available compounds,
reported to be relatively selective inhibitors of particular serine/threonine-specific protein …

Abstract For the Library of Integrated Network-based Cellular Signatures (LINCS) project
many gene expression signatures using the L1000 technology have been produced. The …

The MAP kinase signaling cascade Ras/Raf/MEK/ERK has been involved in a large variety
of cellular and physiological processes that are crucial for life. Many pathological situations …

This article reviews the steps that have led us from very fundamental research on the cell
division cycle, investigated with the starfish oocyte model, to the identification of drugs now …

(R)-Roscovitine (CYC202) is often referred to as a" selective inhibitor of cyclin-dependent
kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis …

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Publications C&EN CAS Find my institution Log In ACS Publications. Most Trusted. Most …

Cyclin B1 is the regulatory subunit of M-phase promoting factor, and proper regulation of
cyclin B1 is essential for the initiation of mitosis. Increasing evidence indicates that the …