Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the …

LK Janssens, K Van Uytfanghe, JB Williams… - Archives of …, 2024 - Springer
Cultivation of industrial low-Δ9-tetrahydrocannabinol (Δ9-THC) hemp has created an
oversupply of cannabidiol (CBD)-rich products. The fact that phytocannabinoids, including …

The 'ABC'of split-nanoluciferase HIF heterodimerization bioassays: Applications, Benefits & Considerations

LK Janssens, CP Stove - Biochemical Pharmacology, 2024 - Elsevier
Hypoxia-inducible factors (HIF) are interesting targets for multiple therapeutic indications.
While HIF activation is desired for the treatment of anemia-related and ischemic diseases …

Interpreting mono-and poly-SCRA intoxications from an activity-based point of view: JWH-018 equivalents in serum as a comparative measure

LK Janssens, MJ Sommer, KE Grafinger… - Archives of …, 2024 - Springer
Synthetic cannabinoid receptor agonists (SCRAs) are a class of synthetic drugs that mimic
and greatly surpass the effect of recreational cannabis. Acute SCRA intoxications are in …

Structure–Activity Relationships, Deuteration, and Fluorination of Synthetic Cannabinoid Receptor Agonists Related to AKB48, 5F-AKB-48, and AFUBIATA

E Sparkes, CJ Maloney, JW Markham… - ACS Chemical …, 2024 - ACS Publications
Synthetic cannabinoid receptor agonists (SCRAs) are a growing class of new psychoactive
substances (NPS) commonly derived from an N-alkylated indole, indazole, or 7-azaindole …

Synthesis and functional evaluation of proteinogenic amino acid-derived synthetic cannabinoid receptor agonists related to MPP-5F-PICA, MMB-5F-PICA, and MDMB …

E Sparkes, JW Markham, R Boyd, M Udoh… - RSC Medicinal …, 2024 - pubs.rsc.org
Synthetic cannabinoid receptor agonists (SCRAs) comprise the second largest class of new
psychoactive substances (NPS), and typically α-amino acid moieties are incorporated as …

[PDF][PDF] Synthetische Cannabinoide in der forensischen Toxikologie:: Studien zur Pharmakokinetik mittels massenspektrometrischer Analyseverfahren in biologischen …

B Haschimi - 2023 - freidok.uni-freiburg.de
Synthetische Cannabinoide (SC) sind eine der bedeutendsten Substanzklassen unter den
sogenannten neuen psychoaktiven Stoffen (NPS) und besitzen aufgrund ihrer …