Objectives. To estimate health outcomes of policies to mitigate the opioid epidemic.
Methods. We used dynamic compartmental modeling of US adults, in various pain, opioid …

Abuse-deterrent opioid formulations have been suggested as one way to decrease the
abuse, addiction, and overdose of orally prescribed opioids. Ten oral opioid formulations …

Objective: Abuse and misuse of prescription opioids is a significant public health concern.
This review examines the strategies used to confer abuse-deterrent properties on opioid …

Opioid abuse is a growing problem and has become a national health crisis over the past
decade in the USA. Oral ingestion, snorting, and injection are the most commonly employed …

Abuse-deterrent formulations of opioid analgesics (ADFs) were introduced to reduce opioid-
related harms among pain patients, but postmarketing study results have been mixed …

Background Prescription opioid abuse and misuse is a serious and growing public health
issue. While the most common form of abuse is swallowing intact tablets/capsules, some …

Tapentadol, a Schedule II opioid with a combination of µ-opioid activity and norepinephrine
reuptake inhibition, is used for the management of moderate to severe acute and chronic …

Purpose Recent limited epidemiologic and case reports suggest that gabapentin is being
misused, especially among prescription opioid misusers. However, no apparent studies …

Background Therapeutic use and abuse of prescription opioids in the United States
increased substantially between 1990 and 2010. The Centers for Disease Control estimated …

Introduction: Non-medical use (NMU) of prescription stimulant medications is a continuing
public health concern. Stimulant medications prescribed for attention-deficit/hyperactivity …