Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …
membranes and associated proteins are linked to the thermodynamics and kinetics of …
Mass spectrometry methods for measuring protein stability
Mass spectrometry is a central technology in the life sciences, providing our most
comprehensive account of the molecular inventory of the cell. In parallel with developments …
comprehensive account of the molecular inventory of the cell. In parallel with developments …
Combining native and 'omics' mass spectrometry to identify endogenous ligands bound to membrane proteins
Ligands bound to protein assemblies provide critical information for function, yet are often
difficult to capture and define. Here we develop a top-down method,'nativeomics', unifying …
difficult to capture and define. Here we develop a top-down method,'nativeomics', unifying …
Membrane protein–lipid interactions probed using mass spectrometry
Membrane proteins that exist in lipid bilayers are not isolated molecular entities. The lipid
molecules that surround them play crucial roles in maintaining their full structural and …
molecules that surround them play crucial roles in maintaining their full structural and …
The effects of sodium ions on ligand binding and conformational states of G protein-coupled receptors—insights from mass spectrometry
The use of mass spectrometry to investigate proteins is now well established and provides
invaluable information for both soluble and membrane protein assemblies. Maintaining …
invaluable information for both soluble and membrane protein assemblies. Maintaining …
Surface-induced dissociation of noncovalent protein complexes in an extended mass range orbitrap mass spectrometer
Native mass spectrometry continues to develop as a significant complement to traditional
structural biology techniques. Within native mass spectrometry (MS), surface-induced …
structural biology techniques. Within native mass spectrometry (MS), surface-induced …
Surface-induced dissociation: an effective method for characterization of protein quaternary structure
METHODS Herein we describe alternative dissociation methods commonly employed within
mass spectrometry with an emphasis on the outcomes of probing native protein complexes …
mass spectrometry with an emphasis on the outcomes of probing native protein complexes …
Targeting bacterial phospholipids and their synthesis pathways for antibiotic discovery
M Song, S Chen, W Lin, K Zhu - Progress in Lipid Research, 2024 - Elsevier
Bacterial infections in humans and animals caused by multidrug-resistant (MDR) pathogens
pose a serious threat to public health. New antibacterial targets are extremely urgent to …
pose a serious threat to public health. New antibacterial targets are extremely urgent to …
Infrared Photoactivation Enables Improved Native Top-Down Mass Spectrometry of Transmembrane Proteins
BR Juliano, JW Keating, BT Ruotolo - Analytical chemistry, 2023 - ACS Publications
Membrane proteins are often challenging targets for native top-down mass spectrometry
experimentation. The requisite use of membrane mimetics to solubilize such proteins …
experimentation. The requisite use of membrane mimetics to solubilize such proteins …