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Lessons from the host defences of bats, a unique viral reservoir
There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
[HTML][HTML] Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC
Severe acute respiratory syndrome coronavirus (SARS-CoV) is capable of inducing a storm
of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame …
of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame …
Age and age-related diseases: role of inflammation triggers and cytokines
Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …
system at older age, with evidence pointing to an inability to fine-control systemic …
Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
Bats are special in their ability to host emerging viruses. As the only flying mammal, bats
endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether …
endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether …
Regulated necrosis: disease relevance and therapeutic opportunities
The discovery of regulated cell death presents tantalizing possibilities for gaining control
over the life–death decisions made by cells in disease. Although apoptosis has been the …
over the life–death decisions made by cells in disease. Although apoptosis has been the …
[HTML][HTML] Oxidative stress and inflammation in COVID-19-associated sepsis: the potential role of anti-oxidant therapy in avoiding disease progression
Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak
emerged, countless efforts are being made worldwide to understand the molecular …
emerged, countless efforts are being made worldwide to understand the molecular …
Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases
Bats are special in their ability to live long and host many emerging viruses. Our previous
studies showed that bats have altered inflammasomes, which are central players in aging …
studies showed that bats have altered inflammasomes, which are central players in aging …