Nanotechnology: a promising approach for cancer diagnosis, therapeutics and theragnosis

M Dessale, G Mengistu… - International Journal of …, 2022 - pmc.ncbi.nlm.nih.gov
Cancer remains the most devastating disease and the major cause of mortality worldwide.
Although early diagnosis and treatment are the key approach in fighting against cancer, the …

Magnetic nanoparticles in targeted drug delivery: a review

E Kianfar - Journal of Superconductivity and Novel Magnetism, 2021 - Springer
Magnetic nanoparticles are one of the most important and widely used types of
nanomaterials, whose unique properties make them special compared to other …

Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

M Schlich, R Palomba, G Costabile… - Bioengineering & …, 2021 - Wiley Online Library
Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system
for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with …

Physiological barriers and strategies of lipid‐based nanoparticles for nucleic acid drug delivery

M Hu, X Li, Z You, R Cai, C Chen - Advanced Materials, 2024 - Wiley Online Library
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …

mRNA nanomedicine: Design and recent applications

LJ Kubiatowicz, A Mohapatra, N Krishnan… - …, 2022 - Wiley Online Library
The rational design and application of mRNA‐based medicine have recently yielded some
key successes in the clinical management of human diseases. mRNA technology allows for …

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

CR Brown, S Gupta, J Qin, T Racie, G He… - Nucleic acids …, 2020 - academic.oup.com
One hallmark of trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNAs is the
remarkable durability of silencing that can persist for months in preclinical species and …

Cancer nanotechnology: a new revolution for cancer diagnosis and therapy

VK Chaturvedi, A Singh, VK Singh… - Current drug …, 2019 - benthamdirect.com
Background: Nanotechnology is gaining significant attention worldwide for cancer treatment.
Nanobiotechnology encourages the combination of diagnostics with therapeutics, which is a …

Overcoming endosomal entrapment in drug delivery

D Pei, M Buyanova - Bioconjugate chemistry, 2018 - ACS Publications
Intracellular delivery of biological agents such as peptides, proteins, and nucleic acids
generally rely on the endocytic pathway as the major uptake mechanism, resulting in their …

[HTML][HTML] Nano-scale delivery systems for siRNA delivery in cancer therapy: New era of gene therapy empowered by nanotechnology

N Ebrahimi, MS Manavi, A Nazari, A Momayezi… - Environmental …, 2023 - Elsevier
RNA interference (RNAi) is a unique treatment approach used to decrease a disease's
excessive gene expression, including cancer. SiRNAs may find and destroy homologous …

Multifunctional mesoporous silica nanoparticles as a universal platform for drug delivery

C Argyo, V Weiss, C Bräuchle, T Bein - Chemistry of materials, 2014 - ACS Publications
Nanosized mesoporous silica particles with high colloidal stability attract growing attention
as drug delivery systems for targeted cancer treatment and as bioimaging devices. This …