The brain is one of the most complex living tissue types and is composed of an exceptional
diversity of cell types displaying unique functional connectivity. Single-cell RNA sequencing …

Recent advancements in modern science have provided robust tools for drug discovery. The
rapid development of transcriptome sequencing technologies has given rise to single-cell …

Major depressive disorder (MDD) is a common, heterogenous, and potentially serious
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …

The molecular organization of the human neocortex historically has been studied in the
context of its histological layers. However, emerging spatial transcriptomic technologies …

The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation
and the development of more effective therapies. Here, we performed single-cell dissection …

Objective: In schizophrenia, somatostatin (SST) and parvalbumin (PV) mRNA levels are
lower in the dorsolateral prefrontal cortex (DLPFC), but it remains unclear whether these …

Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

Neurodevelopmental disorders arise due to various risk factors that can perturb different
stages of brain development, and a combinatorial impact of these risk factors programs the …

Memories are encoded by sparse populations of neurons but how such sparsity arises
remains largely unknown. We found that a neuron's eligibility to be recruited into the memory …

Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …