Platelet proteomes, pathways, and phenotypes as informants of vascular wellness and disease
JE Aslan - Arteriosclerosis, thrombosis, and vascular biology, 2021 - Am Heart Assoc
Platelets rapidly undergo responsive transitions in form and function to repair vascular
endothelium and mediate hemostasis. In contrast, heterogeneous platelet subpopulations …
endothelium and mediate hemostasis. In contrast, heterogeneous platelet subpopulations …
Pathway Commons 2019 Update: integration, analysis and exploration of pathway data
Abstract Pathway Commons (https://www. pathwaycommons. org) is an integrated resource
of publicly available information about biological pathways including biochemical reactions …
of publicly available information about biological pathways including biochemical reactions …
[HTML][HTML] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
[HTML][HTML] Platelet MAPKs—a 20+ year history: What do we really know?
P Patel, UP Naik - Journal of Thrombosis and Haemostasis, 2020 - Elsevier
The existence of mitogen activated protein kinases (MAPKs) in platelets has been known for
more than 20 years. Since that time hundreds of reports have been published describing the …
more than 20 years. Since that time hundreds of reports have been published describing the …
Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs
Platelets engage cues of pending vascular injury through coordinated adhesion, secretion,
and aggregation responses. These rapid, progressive changes in platelet form and function …
and aggregation responses. These rapid, progressive changes in platelet form and function …
Large-scale automated machine reading discovers new cancer-driving mechanisms
PubMed, a repository and search engine for biomedical literature, now indexes> 1 million
articles each year. This exceeds the processing capacity of human domain experts, limiting …
articles each year. This exceeds the processing capacity of human domain experts, limiting …
Unfolded protein response differentially modulates the platelet phenotype
Background: Unfolded protein response (UPR) is a multifaceted signaling cascade that
alleviates protein misfolding. Although well studied in nucleated cells, UPR in absence of …
alleviates protein misfolding. Although well studied in nucleated cells, UPR in absence of …
Causal interactions from proteomic profiles: Molecular data meet pathway knowledge
We present a computational method to infer causal mechanisms in cell biology by analyzing
changes in high-throughput proteomic profiles on the background of prior knowledge …
changes in high-throughput proteomic profiles on the background of prior knowledge …
The toll-like receptor 2 ligand Pam2CSK4 activates platelet nuclear factor-κB and Bruton's tyrosine kinase signaling to promote platelet-endothelial cell interactions
Circulating platelets establish a variety of immunological programs and orchestrate
inflammatory responses at the endothelium. Platelets express the innate immunity family of …
inflammatory responses at the endothelium. Platelets express the innate immunity family of …
Platelet Rho GTPase regulation in physiology and disease
JE Aslan - Platelets, 2019 - Taylor & Francis
Rho GTPases are master orchestrators of cytoskeletal dynamics and serve critical roles in
platelet physiology to promote hemostasis or pathology in thrombotic, inflammatory and …
platelet physiology to promote hemostasis or pathology in thrombotic, inflammatory and …