Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets

Á Nagy, A Lánczky, O Menyhárt, B Győrffy - Scientific reports, 2018 - nature.com
Multiple studies suggested using different miRNAs as biomarkers for prognosis of
hepatocellular carcinoma (HCC). We aimed to assemble a miRNA expression database …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Metabolism‐associated molecular classification of hepatocellular carcinoma

C Yang, X Huang, Z Liu, W Qin, C Wang - Molecular oncology, 2020 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a disease with unique management complexity because
it displays high heterogeneity of molecular phenotypes. We herein aimed to characterize the …

The protein histidine phosphatase LHPP is a tumour suppressor

SK Hindupur, M Colombi, SR Fuhs, MS Matter, Y Guri… - Nature, 2018 - nature.com
Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized
post-translational modification of proteins,. Here we describe a role of histidine …

Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages

CKY Ng, E Dazert, T Boldanova, M Coto-Llerena… - Nature …, 2022 - nature.com
Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage,
HBV-associated HCCs. Here we present an integrated proteogenomic analysis of HCCs …

A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis

N Fujiwara, M Kobayashi, AJ Fobar, A Hoshida… - Med, 2021 - cell.com
Background Accurate non-invasive prediction of long-term hepatocellular carcinoma (HCC)
risk in advanced liver fibrosis is urgently needed for cost-effective HCC screening; however …

Gene expression signature as a surrogate marker of microvascular invasion on routine hepatocellular carcinoma biopsies

A Beaufrère, S Caruso, J Calderaro, N Poté, JC Bijot… - Journal of …, 2022 - Elsevier
Background & Aims Microvascular invasion (MVI), a major risk factor for tumor recurrence
after surgery in hepatocellular carcinoma (HCC), is only detectable by microscopic …

Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals

W Dai, Y Wang, T Yang, J Wang, W Wu… - Cell communication and …, 2019 - Springer
Abstract Background C-Type Lectin Domain Family 3 Member B (CLEC3B), is down-
regulated in serum and tumor tissues in different cancers including hepatocellular …

[HTML][HTML] DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride

LM Liu, DD **ong, P Lin, H Yang… - International …, 2018 - spandidos-publications.com
The aim of the present study was to determine the role of topoisomerase 1 (TOP1) and
topoisomerase 2A (TOP2A) in liver cancer (LC), and to investigate the inhibitory effect of …

A comprehensive genome‐wide analysis of long noncoding RNA expression profile in hepatocellular carcinoma

H Cui, Y Zhang, Q Zhang, W Chen, H Zhao… - Cancer …, 2017 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide,
especially in East Asia and China. Long noncoding RNA s (lnc RNA s) are emerging as …