Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …

During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …

Neuroplasticity refers to the ability of the brain to reorganize and modify its neural
connections in response to environmental stimuli, experience, learning, injury, and disease …

Unhealthy dietary patterns-induced obesity and obesity-related complications pose a great
threat to human health all over the world. Accumulating evidence suggests that the …

Doxorubicin (DOX), as a kind of chemotherapy agent with remarkable therapeutic effect, can
be used to treat diverse malignant tumors clinically. Dose-dependent cardiotoxicity is the …

Microglia-mediated neuroinflammation and mitochondrial dysfunction play critical role in the
pathogenic process of Parkinson's disease (PD). Mitophagy plays central role in …

Inhibition of NLRP3 inflammasome activation produces potent therapeutic effects in a wide
array of inflammatory diseases. Bergapten (BeG), a furocoumarin phytohormone present in …

Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive dysfunction and behavioral impairment. The typical …

Obesity is one of the prominent global health issues, contributing to the growing prevalence
of insulin resistance and type 2 diabetes. Chronic inflammation in adipose tissue is …