Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

ABSTRACT TP53 gene mutations are one of the most frequent somatic events in cancer.
The IARC TP53 Database (http://p53. iarc. fr) is a popular resource that compiles occurrence …

As more clinically relevant cancer genes are identified, comprehensive diagnostic
approaches are needed to match patients to therapies, raising the challenge of optimization …

Tumors are characterized by somatic mutations that drive biological processes ultimately
reflected in tumor phenotype. With regard to radiographic phenotypes, generally …

Background Myelodysplastic syndromes are clinically heterogeneous disorders
characterized by clonal hematopoiesis, impaired differentiation, peripheral-blood …

The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years.
With a 5-year survival rate of∼ 15%, the identification of new therapeutic targets for EAC is …

Human cancer genome sequencing has recently revealed that genes that encode subunits
of SWI/SNF chromatin remodeling complexes are frequently mutated across a wide variety …

Translating whole-exome sequencing (WES) for prospective clinical use may have an
impact on the care of patients with cancer; however, multiple innovations are necessary for …

Langerhans cell histiocytosis (LCH) has a broad spectrum of clinical behaviors; some cases
are self-limited, whereas others involve multiple organs and cause significant mortality …