Physiological implications of hydrogen sulfide: a whiff exploration that blossomed
R Wang - Physiological reviews, 2012 - journals.physiology.org
The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …
Physiology of cell volume regulation in vertebrates
The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …
cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action
SH Francis, JL Busch, JD Corbin, D Sibley - Pharmacological reviews, 2010 - Elsevier
To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …
The transient receptor potential family of ion channels
B Nilius, G Owsianik - Genome biology, 2011 - Springer
The transient receptor potential (TRP) multigene superfamily encodes integral membrane
proteins that function as ion channels. Members of this family are conserved in yeast …
proteins that function as ion channels. Members of this family are conserved in yeast …
Etiology and pharmacology of neuropathic pain
Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …
Transient receptor potential (TRP) channels
A Samanta, TET Hughes… - … complexes: Structure and …, 2018 - Springer
Abstract Transient Receptor Potential (TRP) channels are evolutionarily conserved integral
membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation …
membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
TRPA1 as a therapeutic target for nociceptive pain
D Souza Monteiro de Araujo, R Nassini… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
Membrane fusion and fission events in intracellular trafficking are controlled by both
intraluminal Ca2+ release and phosphoinositide (PIP) signalling. However, the molecular …
intraluminal Ca2+ release and phosphoinositide (PIP) signalling. However, the molecular …
Central mechanisms of osmosensation and systemic osmoregulation
CW Bourque - Nature Reviews Neuroscience, 2008 - nature.com
Systemic osmoregulation is a vital process whereby changes in plasma osmolality, detected
by osmoreceptors, modulate ingestive behaviour, sympathetic outflow and renal function to …
by osmoreceptors, modulate ingestive behaviour, sympathetic outflow and renal function to …