Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE)
is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of …

Ferroptosis is a unique form of cell death caused by excessive iron-dependent lipid
peroxidation. The level of the anabolic reductant NADPH is a biomarker of ferroptosis …

The immune function of normal T cells partially depends on the maneuvering of lipid
metabolism through various stages and subsets. Interestingly, T-cell malignancies also …

The intimate association between the endoplasmic reticulum (ER) and mitochondrial
membranes at ER-Mitochondria contact sites (ERMCS) is a platform for critical cellular …

Background and Purpose Squalene epoxidase (SQLE) is a key enzyme involved in
cholesterol biosynthesis, but growing evidence also reveals that SQLE is abnormally …

Cholesterol synthesis is both energy-and oxygen-intensive, yet relatively little is known of
the regulatory effects of hypoxia on pathway enzymes. We previously showed that the rate …

The polar bear (Ursus maritimus) is the only Arctic land mammal that dives into water to
hunt. Despite thermal insulation provided by blubber and fur layers and low Arctic …

Metabolic-related diseases are chronic diseases caused by multiple factors, such as
genetics and the environment. These diseases are difficult to cure and seriously affect …

Squalene epoxidase (SQLE) is a key enzyme in the mevalonate–cholesterol pathway that
plays a critical role in cellular physiological processes. It converts squalene to 2, 3 …

Cholesterol is essential for both normal cell viability and cancer cell proliferation. Aberrant
activity of squalene monooxygenase (SM, also known as squalene epoxidase), the rate …