Cancer immunotherapy with immune checkpoint inhibitors (ICIs): potential, mechanisms of resistance, and strategies for reinvigorating T cell responsiveness when …
Cancer is still the leading cause of death globally. The approval of the therapeutic use of
monoclonal antibodies against immune checkpoint molecules, notably those that target the …
monoclonal antibodies against immune checkpoint molecules, notably those that target the …
Triple-negative breast cancer: a brief review about epidemiology, risk factors, signaling pathways, treatment and role of artificial intelligence
NM Almansour - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) is a kind of breast cancer that lacks estrogen,
progesterone, and human epidermal growth factor receptor 2. This cancer is responsible for …
progesterone, and human epidermal growth factor receptor 2. This cancer is responsible for …
[HTML][HTML] Enhancing personalized immune checkpoint therapy by immune archety** and pharmacological targeting
Immune checkpoint inhibitors (ICIs) are an expanding class of immunotherapeutic agents
with the potential to cure cancer. Despite the outstanding clinical response in patient …
with the potential to cure cancer. Despite the outstanding clinical response in patient …
Structural probing of HapR to identify potent phytochemicals to control Vibrio cholera through integrated computational approaches
Cholera is a severe small intestine bacterial disease caused by consumption of water and
food contaminated with Vibrio cholera. The disease causes watery diarrhea leading to …
food contaminated with Vibrio cholera. The disease causes watery diarrhea leading to …
Integrated computer-aided drug design and biophysical simulation approaches to determine natural anti-bacterial compounds for Acinetobacter baumannii
RAH Almihyawi, ZT Naman, HMH Al-Hasani… - Scientific reports, 2022 - nature.com
Acinetobacter baumannii is a nosocomial bacterial pathogen and is responsible for a wide
range of diseases including pneumonia, necrotizing fasciitis, meningitis, and sepsis. The …
range of diseases including pneumonia, necrotizing fasciitis, meningitis, and sepsis. The …
Targeting the RBD of omicron variant (B. 1.1. 529) with medicinal phytocompounds to abrogate the binding of spike glycoprotein with the hACE2 using computational …
AR Hakami - Biology, 2022 - mdpi.com
Simple Summary The current study based on virtual drugs screening and simulations
identified novel drugs to target the RBD of the spike protein from Omicron variant of SARS …
identified novel drugs to target the RBD of the spike protein from Omicron variant of SARS …
Bispecific Antibodies, Immune Checkpoint Inhibitors, and Antibody− Drug Conjugates Directing Antitumor Immune Responses: Challenges and Prospects
CL Li, XY Ma, P Yi - Cell Biochemistry and Function, 2024 - Wiley Online Library
Tumor immunotherapy includes bispecific antibodies (BsAbs), immune checkpoint inhibitors
(ICIs), vaccines, and adoptive cell immunotherapy. BsAbs belong to the family of antibodies …
(ICIs), vaccines, and adoptive cell immunotherapy. BsAbs belong to the family of antibodies …
Identification and dynamics of novel scaffolds against Enterococcus faecium serine hydroxymethyltransferase enzyme: a potential target for antibiotics development
Serine hydroxymethyltransferase enzyme is a significant player in purine, thymidylate, and L-
serine biosynthesis and has been tagged as a potential target for cancer, viruses, and …
serine biosynthesis and has been tagged as a potential target for cancer, viruses, and …
[HTML][HTML] Integrated computational approaches to screen gene expression data to determine key genes and therapeutic targets for type-2 diabetes mellitus
FA Alhumaydhi - Saudi Journal of Biological Sciences, 2022 - Elsevier
There is a rapid rise in cases of Type-2-diabetes mellitus (T2DM) globally, irrespective of the
geography, ethnicity or any other variable factors. The molecular mechanisms that could …
geography, ethnicity or any other variable factors. The molecular mechanisms that could …
Structural Dynamics of P‐Rex1 Complexed with Natural Leads Establishes the Protein as an Attractive Target for Therapeutics to Suppress Cancer Metastasis
AR Hameed, SF Ali, SMS Alsallameh… - BioMed Research …, 2023 - Wiley Online Library
Phosphatidylinositol 3, 4, 5‐trisphosphate‐(PIP3‐) dependent Rac exchanger 1 (P‐Rex1)
functions as Rho guanine nucleotide exchange factor and is activated by synergistic activity …
functions as Rho guanine nucleotide exchange factor and is activated by synergistic activity …