Epilepsy is the tendency to have unprovoked epileptic seizures. Anything causing structural
or functional derangement of brain physiology may lead to seizures, and different conditions …

Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy
remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs …

A biomarker is a characteristic that is measured as an indicator of normal biologic
processes, pathogenic processes, or responses to an exposure or intervention, including …

Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

Increasing evidence suggests that inflammatory responses are involved in the progression
of brain injuries induced by a diverse range of insults, including ischemia, hemorrhage …

A biomarker is defined as an objectively measured characteristic of a normal or pathologic
biologic process. Identification and proper validation of biomarkers of epileptogenesis (the …

Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …

Epilepsy is a devastating condition affecting around 70 million people worldwide. Moreover,
the quality of life of people with epilepsy (PWE) is worsened by a series of comorbidities …

A biomarker that will enable the identification of patients at high-risk for develo** post-
injury epilepsy is critically required. Microvascular pathology and related blood–brain barrier …

There are no pharmacological interventions to prevent the development of epilepsy,
although many promising compounds have been identified in the animal laboratory. Clinical …