The yin and yang of ERBB4: tumor suppressor and oncoprotein
Abstract ERBB4 (HER4) is a member of the ERBB family of receptor tyrosine kinases, a
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …
HER3 overexpression and survival in solid tumors: a meta-analysis
Background The human epidermal growth factor receptor 3 (HER3) is an ErbB/HER family
member that dimerizes with other ErbB receptors such as HER2. Numerous agents against …
member that dimerizes with other ErbB receptors such as HER2. Numerous agents against …
The role of ErbB4 in cance r
VFM Segers, L Dugaucquier, E Feyen, H Shakeri… - Cellular oncology, 2020 - Springer
Background The epidermal growth factor receptor family consists of four members, ErbB1
(epidermal growth factor receptor-1), ErbB2, ErbB3, and ErbB4, which all have been found …
(epidermal growth factor receptor-1), ErbB2, ErbB3, and ErbB4, which all have been found …
The ERBB3 receptor in cancer and cancer gene therapy
G Sithanandam, LM Anderson - Cancer gene therapy, 2008 - nature.com
ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its
tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other …
tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other …
A review of HER4 (ErbB4) kinase, its impact on cancer, and its inhibitors
MI El-Gamal, NH Mewafi, NE Abdelmotteleb… - Molecules, 2021 - mdpi.com
HER4 is a receptor tyrosine kinase that is required for the evolution of normal body systems
such as cardiovascular, nervous, and endocrine systems, especially the mammary glands. It …
such as cardiovascular, nervous, and endocrine systems, especially the mammary glands. It …
HER3 comes of age: new insights into its functions and role in signaling, tumor biology, and cancer therapy
MR Campbell, D Amin, MM Moasser - Clinical Cancer Research, 2010 - AACR
The human epidermal growth family (HER) of tyrosine kinase receptors underlies the
pathogenesis of many types of human cancer. The oncogenic functions of three of the HER …
pathogenesis of many types of human cancer. The oncogenic functions of three of the HER …
High expression of HER3 is associated with a decreased survival in gastric cancer
M Hayashi, M Inokuchi, Y Takagi, H Yamada… - Clinical Cancer …, 2008 - AACR
Background: The role of human epidermal growth factor receptor (HER) 3 and HER4 has
been elucidated in gastric cancer. HER1 and HER2 overexpression are regarded as …
been elucidated in gastric cancer. HER1 and HER2 overexpression are regarded as …
The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics
DN Amin, MR Campbell, MM Moasser - Seminars in cell & developmental …, 2010 - Elsevier
Many types of human cancer are characterized by deregulation of the human epidermal
growth factor receptor (HER) family of tyrosine kinase receptors. In some cancers, genomic …
growth factor receptor (HER) family of tyrosine kinase receptors. In some cancers, genomic …
[HTML][HTML] Regulation of ERBB3/HER3 signaling in cancer
ERBB3/HER3 is emerging as a molecular target for various cancers. HER3 is
overexpressed and activated in a number of cancer types under the conditions of acquired …
overexpressed and activated in a number of cancer types under the conditions of acquired …
HER3: toward the prognostic significance, therapeutic potential, current challenges, and future therapeutics in different types of cancer
A Majumder - Cells, 2023 - mdpi.com
Human epidermal growth factor receptor 3 (HER3) is the only family member of the
EGRF/HER family of receptor tyrosine kinases that lacks an active kinase domain (KD) …
EGRF/HER family of receptor tyrosine kinases that lacks an active kinase domain (KD) …