Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

The mammalian lung, like many other organs, develops by branching morphogenesis of an
epithelium [1]. Development initiates with evagination of two ventral buds of foregut …

The p63 gene, a homologue of the tumour-suppressor p53 (–), is highly expressed in the
basal or progenitor layers of many epithelial tissues. Here we report that mice homozygous …

The interactions between fibroblast growth factors (FGF) and their receptors have important
roles in mediating mesenchymal-epithelial cell interactions during embryogenesis 1, 2. In …

Lowering the dosage of a single gene from two copies to one copy in diploid yeast results in
a heterozygote that is sensitized to any drug that acts on the product of this gene. This …

The LIM domain is a zinc finger structure that is present in several types of proteins,
including homeodomain transcription factors, kinases and proteins that consist of several …

Homeobox genes play fundamental roles in development. They can be subdivided into
several subfamilies, one of which is the LIM-homeobox subfamily. The primary structure of …

Congenital abnormalities of the kidney and urinary tract (CAKUT) occur in 1 out of 500
newborns, and constitute approximately 20–30% of all anomalies identified in the prenatal …

The LIM-homeodomain protein Lmxlb plays a central role in dorso-ventral patterning of the
vertebrate limb1. Targeted disruption of Lmxlb results in skeletal defects including hypoplas …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …