Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y **e, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Recent advances in bioremediation of heavy metals and persistent organic pollutants: A review

MA Tufail, J Iltaf, T Zaheer, L Tariq, MB Amir… - Science of the Total …, 2022 - Elsevier
Heavy metals and persistent organic pollutants are causing detrimental effects on the
environment. The seepage of heavy metals through untreated industrial waste destroys the …

A critical review on the formation, fate and degradation of the persistent organic pollutant hexachlorocyclohexane in water systems and waste streams

S Adithya, RS Jayaraman, A Krishnan, R Malolan… - Chemosphere, 2021 - Elsevier
The environmental impacts of persistent organic pollutants (POPs) is an increasingly
prominent topic in the scientific community. POPs are stable chemicals that are accumulated …

Exploring bioremediation strategies for heavy metals and POPs pollution: the role of microbes, plants, and nanotechnology

A Karnwal, S Martolia, A Dohroo… - Frontiers in …, 2024 - frontiersin.org
Heavy metal and Persistent Organic Pollutants (POPs) pollution stemming from
industrialization, intensive agriculture, and other human activities pose significant …

Cardiotoxicity hazard and risk characterization of toxcast chemicals using human induced pluripotent stem cell-derived cardiomyocytes from multiple donors

SD Burnett, AD Blanchette, WA Chiu… - Chemical research in …, 2021 - ACS Publications
Heart disease remains a significant human health burden worldwide with a significant
fraction of morbidity attributable to environmental exposures. However, the extent to which …

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes as an in vitro model in toxicology: strengths and weaknesses for hazard identification and risk …

SD Burnett, AD Blanchette, WA Chiu… - Expert opinion on drug …, 2021 - Taylor & Francis
Introduction Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes is one of
the most widely used cell-based models that resulted from the discovery of how non …

Preparation of nitrogen doped silica photocatalyst for enhanced photodegradation of polychlorinated biphenyls (PCB-209)

C Li, N Wu, Y Qi, J Liu, X Pan, J Ge, S Wang… - Chemical Engineering …, 2021 - Elsevier
The development of chemically stable and efficient photocatalyst for persistent organic
pollutants (POPs) disposal is highly significant and remains a major challenge. In this work …

Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs

Y Liu, C Sakolish, Z Chen, DTT Phan, RHF Bender… - Toxicology, 2020 - Elsevier
Angiogenesis is a complex process that is required for development and tissue regeneration
and it may be affected by many pathological conditions. Chemicals and drugs can impact …

PCB sulfates in serum from mothers and children in urban and rural US communities

D Zhang, P Saktrakulkla, RF Marek… - … science & technology, 2022 - ACS Publications
Serum samples from 24 subjects (6 mother–daughter and 6 mother–son dyads) in a rural
community (Columbus Junction, Iowa) and 24 subjects (6 mother–daughter and 6 mother …

Characterizing PFAS hazards and risks: a human population-based in vitro cardiotoxicity assessment strategy

LC Ford, HC Lin, YH Zhou, FA Wright, VK Gombar… - Human Genomics, 2024 - Springer
Per-and poly-fluoroalkyl substances (PFAS) are emerging contaminants of concern because
of their wide use, persistence, and potential to be hazardous to both humans and the …