Pathophysiological, epidemiological, and genetic studies provide strong evidence that
lipoprotein (a)[Lp (a)] is a causal mediator of cardiovascular disease (CVD) and calcific …

Calcific aortic valve disease (CAVD) is the most common disorder affecting heart valves and
is characterized by thickening, fibrosis and mineralization of the aortic valve leaflets …

Abstract Background: Lipoprotein (a)[Lp (a)], a major carrier of oxidized phospholipids
(OxPL), is associated with an increased incidence of aortic stenosis (AS). However, it …

Epidemiological and clinical studies over the past decade have firmly established that
elevated plasma concentrations of lipoprotein (a)(Lp (a)) are an important, independent and …

Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing
prevalence in western societies. Statins are widely applied in atherosclerosis therapy …

Oxidized phospholipids (OxPL) are key mediators of the pro-atherosclerotic effects of
oxidized lipoproteins. They are particularly important for the pathogenicity of lipoprotein …

Prolonged or excessive exposure to oxidized phospholipids (OxPLs) generates chronic
inflammation. OxPLs are present in atherosclerotic lesions and can be detected in plasma …

Summary Lipoprotein (a)[Lp (a)] is an apolipoprotein B (apoB)-containing plasma lipoprotein
similar in structure to low-density lipoprotein (LDL). Lp (a) is more complex than LDL due to …

Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …

Calcific aortic valve disease (CAVD), previously thought to represent a passive
degeneration of the valvular extracellular matrix (VECM), is now regarded as an intricate …