Background: The heart is the central organ of the circulatory system, which maintains the
flow of blood along with the transport of nutrients to different cells and tissues. A well …

Abstract This Committee Report provides methodological, interpretive, and reporting
guidance for researchers who use measures of heart rate (HR) and heart rate variability …

Atrial fibrillation (AF) is a common cardiac arrhythmia resulting in increased risk of stroke.
Despite highly heritable etiology, our understanding of the genetic architecture of AF …

Abstract Motivation The results from Genome-Wide Association Studies (GWAS) on
thousands of phenotypes provide an unprecedented opportunity to infer the causal effect of …

Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …

Darwin emphasized the intimate relationship between the brain and the heart over 150
years ago. Healthy aging is associated with significant changes in both the brain and the …

Biological age measures outperform chronological age in predicting various aging
outcomes, yet little is known regarding genetic predisposition. We performed genome‐wide …

Atrial fibrillation (AF) is the most common clinical tachyarrhythmia with a strong tendency to
progress in time. AF progression is driven by derailment of protein homeostasis, which …

Individuals with schizophrenia have a reduced life-expectancy compared to the general
population, largely due to an increased risk of cardiovascular disease (CVD). Clinical and …

Background: The concept of chemical agents having properties that confer potential hazard
called key characteristics (KCs) was first developed to identify carcinogenic hazards …